IQGAP2 is a scaffolding protein involved in regulating cell morphology and motility through its interactions with the cytoskeleton, cell adhesion molecules, and various signaling pathways. It contains multiple functional domains, including three IQ motifs, a calponin homology domain, a Ras-GAP domain, and a WW domain. IQGAP2 binds to activated forms of CDC42 and RAC1 but does not promote their GTPase activity. Expressed in the liver, stomach, and platelets, IQGAP2 shares over 50% sequence identity with IQGAP1, yet appears to differ significantly in its pathological roles.
