Heterotrimeric G proteins are composed of three subunits: G , G , and G , and transmit signals from activated G protein-coupled receptors (GPCRs) to intracellular pathways. The G subunit exists in several subtypes, including Gi, Go, Gz, and Gt, which are collectively involved in modulating downstream signaling. GNAI2 encodes the alpha-2 subunit of the Gi class in humans. Gi proteins are known to inhibit adenylate cyclase activity in response to hormonal signals and may also participate in regulating cell division.
IgG1 mouse antibody generated against rat Gi alpha2 and recognizes rodent and human homologs.
Applications include western blot.
