Cadherin-1 (CDH1) is a key member of the cadherin superfamily, functioning as a calcium-dependent cell-cell adhesion glycoprotein. The protein is composed of five extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail. CDH1 plays an essential role in regulating epithelial cell adhesion, motility, and proliferation. Mutations in the CDH1 gene have been implicated in various cancers, including gastric, breast, colorectal, thyroid, and ovarian malignancies.
Mouse IgG1 monoclonal antibody generated against human E-cadherin (partial, amino acids 155- 707) and recognizes human and dog E-cadherin (Epithelial-cadherin).
Applications include ELISA, immunopreciptation, immunocytochemistry, and western blot.
