CD40 is a costimulatory receptor expressed on antigen-presenting cells, including B cells, and plays a critical role in their activation and functional maturation. B cell development requires multiple signals, including antigen presentation via MHC, cytokine exposure (such as IL-2, IL-4, and IL-5), and receptor-mediated costimulation. Interaction between CD40 and its ligand CD154 (CD40L), which is expressed on activated T helper cells, promotes B cell maturation and the acquisition of downstream effector functions.
Mouse IgG1 antibody generated against human activated tonsillar B cells.
Applications include flow cytometry, immunohistochemistry, and western blot.
