Clostridium botulinum is a Gram-positive bacterium that produces neurotoxins; A through G. Botulinum neurotoxins (BoNTs) induce paralysis of peripheral neurons by inhibiting the formation of neurotransmitter-carrying vesicles to the plasma membrane. Botulinum toxin type E (BoNT/E) is a zinc protease responsible for cleavage of synaptosomal-associated protein 25 (SNAP25) between residues 180 and 181, consequently inhibiting the formation of synaptic vesicles.
This antibody recognizes catalytic light chain of Botulinum toxin type E (BoNT/E). The light chain (Lc) of BoNT/E has a molecular weight of 50 kDa. Recombinant BoNT/E was used as the immunogen. It is routinely tested by ELISA and western blot.
Applications include ELISA and immunoblotting.
keywords: CET, BoNT, BoNT/E, botulinum neurotoxins, Botulinum toxin type E, synaptosomal-associated protein 25, SNAP25, Anti-BoNT, Anti-BoNT/E, Anti-Botulinum toxin type E
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