Telomeres, the specialized end structures of chromosomes, contain tandem nucleotide TTAGGG repeats that form nucleoprotein complexes required for replication. The telomeric repeat binding factor 1 (TRF1) is one component of human telomeres and it has been proposed that its function involves regulating telomere elongation. With the postulation that telomere dysfunction and telomerase activation may play important roles in prostate tumorigenesis and loss of genome integrity during breast cancer development, an antibody to TRF1 is a valuable asset in cancer research and other studies.
This antibody recognizes the human telomeric repeat binding factor 1 (TRF1). Full length recombinant human TRF1 was used as immunogen. It was produced in cell culture supernatant and contains 0.005% Thimerosal as a preservative. The antibody is routinely tested by western blot.
Applications include western blot.
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