Sauvagine is a 40-residue peptide isolated and characterized from frog skin. It shares significant structural homology with and elicits similar biological responses as corticotropin-releasing factor (CRF). It has high affinity for both the CRF1 and CRF2 receptors (and low affinity for the CRF binding protein), suggesting its potential as a pharmacological tool for the study of these receptor sub-types. Due to the binding to CRF2 receptors and their role in the release of ACTH and beta-endorphin during stress, possible areas of research with this ligand include anxiety, depression and obesity.
This antibody recognizes the 40-amino-acid peptide, sauvagine. Synthetic sauvagine was used as immunogen. The antibody is routinely tested by dot blot.
Applications include immunoblotting.
keywords: Sauvagine, corticotropin-releasing factor, CRF, CRF1, CRF2, ACTH, Beta-Endorphin, Endorphin-Beta, ß-Endorphin, Anti-Sauvagine, brain, neuroscience
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