Beta-endorphin, a potent analgesic opioid peptide is derived from the precursor hormone ‘proopiomelanocortin,’ and is localized mainly in brain regions such as the hypothalamus, brain stem, and pituitary gland. Beta-endorphin is an endogenous peptide which functions as a selective agonist for the mu-opioid receptors. These small-chain peptides produce feelings of well-being, tolerance to pain, etc. These compounds are hundreds or even thousands of times more potent than morphine on a molar basis. Because of this potency, their concentrations in vivo are low.
This antibody recognizes mammalian beta-endorphin. Synthetic beta-endorphin was used as immunogen. The antibody is routinely tested by dot blot. If used in western blot, this antibody may recognize the parent molecules of beta-endorphin. See cited references for details.
Applications include immunoblotting and radioimmunoassay.
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