Adrenocorticotropic hormone (ACTH or corticotropin) stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. ACTH is secreted from the anterior pituitary in response to corticotropin-releasing hormone from the hypothalamus. The corticotropin-releasing hormone is secreted in response to many types of stress.
This antibody recognizes mammalian ACTH. The immunogen was raised in rabbits against the synthetic human ACTH 1-39. The antibody is routinely tested by dot blot.
Applications include immunostaining, immunoblotting, immunohistochemistry, and radioimmunoassay.
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