Corticotropin-releasing hormone/factor (CRH/CRF) is the principal neuropeptide involved in regulating the stress response. It stimulates ACTH release from the pituitary gland. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients.
This antibody recognizes human and rat corticotropin-releasing hormone/factor. The immunogen was raised in rabbits against the synthetic fragment of rat CRF (1-41). The antibody is routinely tested by dot blot.
Applications include radioimmunoassay, affinity chromatography, immunoblotting, immunostaining and immunocytochemistry.
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