Targeting Trends Newsletter 16q2

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The latest edition of Targeting Trends, the quarterly newsletter from Advanced Targeting Systems, is now available online.  I hope you will enjoy our new look as we continue to harmonize our digital platform, from the redesigned website to our e-commerce promotions and this periodical.  Our cover article, Cerebral cholinergic lesion reduces operant responses to unpleasant thermal stimuli, further emphasizes the profound effects and uses of 192-IgG-SAP as a lesioning tool and is contributed by two experts in the use of Saporin conjugates, Drs. Ron Wiley and Charles Vierck.

Along with the new release of vesicular GABA transporter (vGAT)-related products and our new stable transfected cell lines, our Letter from the President addresses the exciting work of human sighs and the researcher that’s ‘gone viral.’  For the next installment of a long and ongoing discussion about the safety of Saporin in the lab and clinic, check out Targeting Talk. Lastly, our feline ATS mascot has initiated a new contest with hundreds of dollars of product credit at stake!

Cerebral cholinergic lesion reduces operant responses to unpleasant thermal stimuli

by Ronald G. Wiley, M.D., Ph.D., Departments of Neurology and Pharmacology, Vanderbilt University, Nashville, TN  and C. J. Vierck, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA

From the President: A Sigh is (Not) Just a Sigh . . .

Targeting Toolbox:

Recent Scientific References and Publications

  • Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. (2016) The peptidergic control circuit for sighing. Nature 530(7590):293-297. PMID: 26855425 (Cat. #IT-40, Cat. #IT-21)
  • Vierck CJ, Yezierski RP, Wiley RG. (2016) Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat. Neuroscience 319:23-34. PMID: 26812034 (Cat. #IT-01)
  • Fu R, Chen X, Zuo W, Li J, Kang S, Zhou LH, Siegel A, Bekker A, Ye JH. (2016) Ablation of mu opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors. Neuropharmacology 107:58-67. PMID: 26921770 (Cat. #IT-12, Cat. #IT-21)
  • Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH. (2016) Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc R Soc B 283(1826):20152978.  (Cat. #AB-N39)
  • Yaksh TL, Fisher C, Hockman T, Wiese A. (2016) Current and Future Issues in the development of spinal agents for the management of pain. Curr Neuropharmacol PMID: 26861470 (Cat. #IT-11)
  • Hulsey DR, Hays SA, Khodaparast N, Ruiz A, Das P, Rennaker RLn, Kilgard MP. (2016) Reorganization of Motor Cortex by Vagus Nerve Stimulation Requires Cholinergic Innervation. Brain Stimul 9(2):174-181. PMID: 26822960 (Cat. #IT-01, Cat. #IT-18)
  • Lee JE, Jeong da U, Lee J, Chang WS, Chang JW. (2016) The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia. BMC Neurol 16(1):6. PMID: 26757896 (Cat. #IT-01)
  • Gulino R. (2016) Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease. Neural Plast 2016:2769735. PMID: 26862439 (Cat. #IT-14)
  • Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y. (2016) Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer. Clin Res Hepatol Gastroenterol PMID: 26774363 (Cat. #IT-04)
  • Petrosini L, De Bartolo P, Cutuli D, Gelfo F. (2016) Perinatal 192 IgG-Saporin as Neuroteratogen. Curr Top Behav Neurosci 29:111-123. PMID: 26695170 (Cat. #IT-01)
  • Archer T, Kostrzewa RM. (2016) Neuroteratology and Animal Modeling of Brain Disorders. Curr Top Behav Neurosci 29:1-40. PMID: 26857462 (Review)
  • Schwartz MD, Nguyen AT, Warrier DR, Palmerston JB, Thomas AM, Morairty SR, Neylan TC, Kilduff TS. (2016) Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep. eNeuro 3(2) PMID: 27022631 (Cat. #IT-03, IT-20)

Creative Captions: Send us your caption for Kermit’s hijinks.
The winning caption will be posted in the next newsletter and the author will receive a $350 product credit, runner-up will receive $100 product credit.

Talking About Targeting: Saporin Safety – Nothing to Fear

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