Targeting Topics Top 20

Kilgard MP, Merzenich MM. (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279(5357):1714-1718. (Cat. #IT-01) – 888 citations

Lu J, Sherman D, Devor M, Saper CB. (2006) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589-594. (Cat. #IT-20) – 494 citations

Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, Li J, Daughters RS, Lappi DA, Wiley RG, Simone DA. (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 278(5336):275-279. (Cat. #IT-08) – 486 citations

Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280(48):40364-40374. (Cat. #IT-08) – 402 citations

Berger-Sweeney J, Heckers S, Mesulam MM, Wiley RG, Lappi DA, Sharma M. (1994) Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. J Neurosci 14(7):4507-4519. (Cat. #IT-01) – 377 citations

Heckers S, Ohtake T, Wiley RG, Lappi DA, Geula C, Mesulam MM. (1994) Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor. J Neurosci 14(3 Pt 1):1271-1289. (Cat. #IT-01) – 364 citations

Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL. (2001) Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4(9):927-930. (Cat. #IT-07) – 357 citations

McGaughy J, Kaiser T, Sarter M. (1996) Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110(2):247-265. (Cat. #IT-01) – 339 citations

Nichols ML, Allen BJ, Rogers SD, Ghilardi JR, Honore P, Luger NM, Finke MP, Li J, Lappi DA, Simone DA, Mantyh PW. (1999) Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 286(5444):1558-1561. (Cat. #IT-07) – 335 citations

Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH. (2002) Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5(12):1319-1326. (Cat. #IT-07) – 327 citations

Lee MG, Chrobak JJ, Sik A, Wiley RG, Buzsaki G. (1994) Hippocampal theta activity following selective lesion of the septal cholinergic system. Neuroscience 62(4):1033-1047. (Cat. #IT-01) – 325 citations

Wiley RG, Oeltmann TN, Lappi DA. (1991) Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Res 562(1):149-153. (Cat. #IT-01) – 321 citations

Baxter MG, Bucci DJ, Gorman LK, Wiley RG, Gallagher M. (1995) Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats. Behav Neurosci 109(4):714-722. (Cat. #IT-01) – 289 citations

Torres EM, Perry TA, Blockland A, Wilkinson LS, Wiley RG, Lappi DA, Dunnet SB. (1994) Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63(1):95-122. (Cat. #IT-01) – 284 citations

Giulian D, Haverkamp LJ, Yu JH, Karshin W, Tom D, Li J, Kirkpatrick J, Kuo LM, Roher AE. (1996) Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci 16(19):6021-6037. (Cat. #IT-08) – 276 citations

Chiba AA, Bucci DJ, Holland PC, Gallagher M. (1995) Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing. J Neurosci 15(11):7315-7322. (Cat. #IT-01) – 236 citations

Burgess SE, Gardell LR, Ossipov MH, Malan TPJ, Vanderah TW, Lai J, Porreca F. (2002) Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22(12):5129-5136. (Cat. #IT-12) – 230 citations

Truitt WA, Coolen LM. (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297(5586):1566-1569. (Cat. #IT-11) – 227 citations

Wenk GL, Stoehr JD, Quintana G, Mobley S, Wiley RG. (1994) Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats. J Neurosci 14(10):5986-5995. (Cat. #IT-01) – 219 citations

Vnek N, Kromer LF, Wiley RG, Rothblat LA. (1996) The basal forebrain cholinergic system and object memory in the rat. Brain Res 710(1-2):265-270. (Cat. #IT-01) – 208 citations