Targeting Trends Newsletter 14q1

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Newsletter Highlights

  • Tribute to Gangsta: A much-loved cat bids us adieu (page 2-7)
  • Spring Brain Conference 25th Anniversary (page 2)
  • Research Tools to Investigate Itch (page 7)
  • Complete and Submit the Targeting Teaser online!

FDA Gives Green Light to Human Clinical Trials for Cancer Pain
(continued on page 6)

Contributed by Douglas A. Lappi, Ph.D., President/Chief Scientific Officer, Advanced Targeting Systems, San Diego, CAProduct information related to cover article: SP-SAP

Spring Brain Conference 25th Anniversary
Come to SBC in Sedona, AZ, March 19-22, 2014

Targeting Teaser Winners

Recent Scientific References (read summaries)

  • Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. (2013) BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A 110(48):19567-19572. (Cat. #AB-N01)
  • Kucinski A, Paolone G, Bradshaw M, Albin RL, Sarter M. (2013) Modeling fall propensity in Parkinson’s disease: deficits in the attentional control of complex movements in rats with cortical-cholinergic and striatal-dopaminergic deafferentation. J Neurosci 33(42):16522-16539. (Cat. #IT-01)
  • Brown DC, Agnello K. (2013) Intrathecal substance p-saporin in the dog: efficacy in bone cancer pain. Anesthesiology 119(5):1178-1185. (SP-SAP)
  • Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. (2013) Intrathecal substance p-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology 119(5):1163-1177. (SP-SAP)
  • Hayashida K. (2013) Substance P-Saporin for Bone Cancer Pain in Dogs: Can Man’s Best Friend Solve the Lost in Translation Problem in Analgesic Development? Anesthesiology 119(5):999-1000. (SP-SAP)
  • Parent MJ, Cyr M, Aliaga A, Kostikov A, Schirrmacher E, Soucy JP, Mechawar N, Rosa-Neto P, Bedard MA. (2013) Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Res 3(1):70. (Cat. #IT-01)
  • Li AJ, Wang Q, Dinh TT, Wiater MF, Eskelsen AK, Ritter S. (2013) Hindbrain Catecholamine Neurons Control Rapid Switching of Metabolic Substrate Use during Glucoprivation in Male Rats. Endocrinology 154(12):4570-4579. (Cat. #IT-03, Cat. #PR-01)
  • Lee LC, Rajkumar R, Dawe GS. (2014) Selective lesioning of nucleus incertus with corticotropin releasing factor-saporin conjugate. Brain Res 1543:179-190. (Cat. #IT-13, Cat. #IT-21)
  • Grupe M, Paolone G, Jensen AA, Sandager-Nielsen K, Sarter M, Grunnet M. (2013) Selective potentiation of (alpha4)3(beta2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats. Biochem Pharmacol 86(10):1487-1496. (Cat. #IT-01)
  • Romano A, Potes CS, Tempesta B, Cassano T, Cuomo V, Lutz T, Gaetani S. (2013) Hindbrain noradrenergic input to the hypothalamic PVN mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. Am J Physiol Endocrinol Metab 305(10):E1266-73. (Cat. #IT-03, Cat. #IT-18)
  • Bitzenhofer SH, Hanganu-Opatz IL. (2013) Oscillatory coupling within neonatal prefrontal-hippocampal networks is independent of selective removal of GABAergic neurons in the hippocampus. Neuropharmacology 77C:57-67. (Cat. #IT-71, Cat. #AB-N44)
  • Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. (2013) Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther 347(2):258-264. (Cat. #AB-N33AP)
  • da Silva EF, Freiria-Oliveira AH, Custodio CH, Ghedini PC, Bataus LA, Colombari E, de Castro CH, Colugnati DB, Rosa DA, Cravo SL, Pedrino GR. (2013) A1 noradrenergic neurons lesions reduce natriuresis and hypertensive responses to hypernatremia in rats. PLoS One 8(9):e73187. (Cat. #IT-03, Cat. #PR-01)
  • Freiria-Oliveira AH, Blanch GT, De Paula PM, Menani JV, Colombari DS. (2013) Lesion of the commissural nucleus of the solitary tract/A2 noradrenergic neurons facilitates the activation of angiotensinergic mechanisms in response to hemorrhage. Neuroscience 254:196-204. (Cat. #IT-03, Cat. #IT-18)
  • Laursen B, Mork A, Plath N, Kristiansen U, Frank Bastlund J. (2014) Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration. Brain Res 1543:253-262. (Cat. #IT-16)
  • Kinikoglu B, Kong Y, Liao EC. (2013) Characterization of cultured multipotent zebrafish neural crest cells. Exp Biol Med (Maywood) Epub(Cat. #AB-N01AP)
  • Baxter MG, Bucci DJ, Gorman LK, Wiley RG, Gallagher M. (2013) Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats. Behav Neurosci 127(5):619-627. (Cat. #IT-01)
  • Leoni G, Rattray M, Fulton D, Rivera A, Butt AM. (2014) Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. J Anat 224(2):216-227. (Cat. #IT-04)
  • Hess SM, Young EF, Miller KR, Vincent BG, Buntzman AS, Collins EJ, Frelinger JA, Hess PR. (2013) Deletion of naive T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance. Transpl Immunol 29(1-4):138-145. (Cat. #IT-27)

Targeting Talk: Product Questions

Upcoming Events

  • American Association for Cancer Research / April 5-9, 2014/ San Diego, CA / Booth #1645
  • Experimental Biology / April 26-30, 2014 / San Diego, CA / Booth #1342

FDA Gives Green Light to Human Clinical Trials for Cancer Pain (continued from page 1)

Recent Scientific References continued

Targeting Tools: Investigating the Itch Pathway

Gangsta Gallery

Targeting Technology Tutorial

Targeting Teaser (Jumble) – Win a Tote Bag!