Targeting Trends Newsletter 13q1

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Newsletter Highlights

  • SFN 2012 Winners (page 2)
  • Spring Brain Conference, March 20-23, 2013 (page 5)
  • Anti-ChAT-SAP (page 7)
  • Complete and Submit the Targeting Teaser online!

Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology (continued on page 6)

Contributed by François LaPlante. Dept of Psychiatry, McGill University, Montréal, QC, Canada Product information related to cover article: Anti-ChAT-SAP (Cat. #IT-42), Rabbit IgG-SAP (Cat. #IT-35)

Society for Neuroscience Poster of the Year

  • Winner (read winning abstract): The GRP peptide and the GRPR-positive interneurons control fear acquisition and extinction. K Zushida, K Light, S Uchida, C Hevi, G P Shumyatsky. (featuring IT-40 Bombesin-SAP)
  • Honorable Mention: Combined loss of entorhinal and basal forebrain cholinergic hippocampal inputs deeply impairs spatial navigation memory in C57BL/6J and hAPPxapoE mice. C Mathis, P-H Moreau, C Zerbinatti, R Goutagny, B Cosquer, K Geiger, C Kelche, J-C Cassel. (featuring IT-16 mu p75-SAP)
  • Honorable Mention: Neuromedin B serves a role in nociceptive signaling. S K Mishra, S Holzman, M A Hoon. (featuring Custom Conjugations)

Recent Scientific References (read summaries)

  • Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, McMullen NT, Rance NE. (2012) Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proc Natl Acad Sci U S A 109(48):19846-19851. (Cat. #IT-63, Cat. #IT-21)
  • Tuscano JM, Kato J, Pearson D, Xiong C, Newell L, Ma Y, Gandara DR, O’Donnell RT. (2012) CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy. Cancer Res 72(21):5556-5565. (Cat. #IT-04)
  • Zant JC, Rozov S, Wigren HK, Panula P, Porkka-Heiskanen T. (2012) Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons. J Neurosci 32(38):13244-13254. (Cat. #IT-01)
  • Croxson PL, Browning PG, Gaffan D, Baxter MG. (2012) Acetylcholine facilitates recovery of episodic memory after brain damage. J Neurosci 32(40):13787-13795. (Cat. #IT-15)
  • Estevez ME, Fogerson PM, Ilardi MC, Borghuis BG, Chan E, Weng S, Auferkorte ON, Demb JB, Berson DM. (2012) Form and function of the M4 cell, an intrinsically photosensitive retinal ganglion cell type contributing to geniculocortical vision. J Neurosci 32(39):13608-13620. (Cat. #AB-N38)
  • Kerbler GM, Hamlin AS, Pannek K, Kurniawan ND, Keller MD, Rose SE, Coulson EJ. (2012) Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. Neuroimage 66C:133-141. (Cat. #IT-16, Cat. #IT-35)
  • Berstad MB, Weyergang A, Berg K. (2012) Photochemical internalization (PCI) of HER2-targeted toxins: Synergy is dependent on the treatment sequence. Biochim Biophys Acta 1820(12):1849-1858. (Cat. #IT-27)
  • Babalola PA, Fitz NF, Gibbs RB, Flaherty PT, Li PK, Johnson DA. (2012) The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem 98(3):303-310. (Cat. #IT-01)
  • Laursen B, Mork A, Plath N, Kristiansen U, Bastlund JF. (2013) Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice. Behav Brain Res 240:146-152. (Cat. #IT-16)
  • Alvarez P, Chen X, Bogen O, Green PG, Levine JD. (2012) IB4(+) nociceptors mediate persistent muscle pain induced by GDNF. J Neurophysiol 108(9):2545-2553. (Cat. #IT-10)
  • Kato J, Satake N, O’Donnell RT, Abuhay M, Lewis C, Tuscano JM. (2013) Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia. Leuk Res 37(1):83-88. (Cat. #IT-18)
  • Daniels-Wells TR, Helguera G, Rodriguez JA, Leoh LS, Erb MA, Diamante G, Casero D, Pellegrini M, Martinez-Maza O, Penichet ML. (2013) Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1. Toxicol In Vitro 27(1):220-231. (Custom Conjugate)
  • Anaclet C, Lin JS, Vetrivelan R, Krenzer M, Vong L, Fuller PM, Lu J. (2012) Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. J Neurosci 32(50):17970-17976. (Cat. #IT-20)
  • Vetrivelan R, Fuller PM, Yokota S, Lu J, Saper CB. (2012) Metabolic effects of chronic sleep restriction in rats. Sleep 35(11):1511-1520. (Cat. #IT-20)

Upcoming Events

  • Spring Brain Conference (SBC) / March 20-23, 2013 / Sedona, AZ
  • American Association for Cancer Research (AACR) / April 4-10, 2013 / Washington DC

Spring Brain Conference – Keynote Speakers

  • Seymour Reichlin, MD, PhD, Tufts Univ School of Medicine “Did Goliath Have a Growth Hormone Secreting Pituitary Adenoma Compressing His Optic Nerves? (And What Does That Have to Do with the Birth of Neuroendocrinology?)”
  • Hans S Keirstead, Professor, University of California at Irvine “Stem Cell-Based Approaches to Treat Spinal Cord Injury”
  • Mark Baxter, Professor, Mount Sinai School of Medicine “Animal models of cognitive impairment after general anesthesia: From the grave to the cradle”

Register today at

Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology (continued from page 1)

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Recent Scientific References (continued from pages 3-4)

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