Targeting Trends Newsletter 11q3

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Newsletter Highlights

  • Incubator Labs; IBRO Abstracts (page 2)
  • Cytotoxicity Assays (page 5)
  • Teaser Winners (page 6)
  • New Antibody Conjugates (page 7)
  • Complete and Submit the Targeting Teaser online!

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results – read article (continued on page 6)

Contributed by Douglas A. Lappi, Ph.D., Advanced Targeting Systems, San Diego, CA USA

Product information related to cover article: Targeted Toxins

Advanced Targeting Systems Opens Incubator Labs – San Diego Biotechnology Center

Abstracts at the 8th IBRO World Congress of Neuroscience, Florence, ITALY – July 14-18, 2011. Congratulations to scientists with abstracts using ATS products: Excerpts from IBRO abstracts

Recent Scientific References (read online)

  • Angelucci F, Gelfo F, Bartolo PD, Caltagirone C, Petrosini L. (2011) BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Neurochem Int (Cat. #IT-01)
  • Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG. (2011) Selective formation of covalent protein heterodimers with an unnatural amino acid. Chem Biol 18(3):299-303. (Cat. #AB-15HRP)
  • King T, Qu C, Okun A, Mercado R, Ren J, Brion T, Lai J, Porreca F. (2011) Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain (Cat. #IT-11, Cat. #IT-21)
  • Larsson M, Broman J. (2011) Synaptic plasticity and pain: role of ionotropic glutamate receptors. Neuroscientist 17(3):256-273. (Cat. #IT-11)
  • Luo T, Leung LS. (2011) Involvement of Tuberomamillary Histaminergic Neurons in Isoflurane Anesthesia. Anesthesiology (Cat. #IT-20)
  • Radley JJ, Sawchenko PE. (2011) A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response. J Neurosci 31(26):9683-9695. (Cat. #IT-32, Cat. #IT-18)
  • St Peters M, Demeter E, Lustig C, Bruno JP, Sarter M. (2011) Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitry. J Neurosci 31(26):9760-9771. (Cat. #IT-01, Cat. #IT-18)
  • Marshall RS, D’Avila F, Di Cola A, Traini R, Spano L, Fabbrini MS, Ceriotti A. (2011) Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress. Plant J 65(2):218-229. (Cat. #AB-15)
  • Mitra N, Banda K, Altheide T, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A. (2011) SIGLEC12: A human-specific segregating (PSEUDO) gene encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem (Cat. #IT-04)
  • Tai SK, Ma J, Ossenkopp KP, Leung LS. (2011) Activation of immobility-related hippocampal theta by cholinergic septohippocampal neurons during vestibular stimulation. Hippocampus (Cat. #IT-01)
  • Wilkinson KA, Fu Z, Powell FL. (2011) Ventilatory Effects of Substance P-Saporin Lesions in the Nucleus Tractus Solitarii of Chronically Hypoxic Rats. Am J Physiol Regul Integr Comp Physiol (Cat. #IT-11, Cat. #IT-21)

Flow Cytometry Protocol – A new protocol has been added on staining for flow cytometry: Protocols for ATS Products

Targeting Talk (see text)

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results (continued from page 1)

Upcoming Events

  • International Brain Res Org / July 14-18, 2011 / Florence, Italy / Booth #12
  • Society for Neuroscience / November 12-16, 2011 / Washington, DC / Booth #616

Targeting Teaser Winners

Targeting Tools: New Antibody Conjugates with Alexa488 or Biotin

  • Angiotensin II: AB-N25AP, AB-N26AP, AB-N27AP, AB-N28AP
  • Dopamine Transporter: AB-N17, AB-N18
  • Mac-1 (CD11b): AB-N05, AB-N06
  • GAD65: AB-N12, AB-N13
  • Somatostatin Receptor: AB-N20AP, AB-N21AP, AB-N24, AB-N35
  • Saporin: AB-15AP, AB-17AP
  • CD25: AB-18, AB-19
  • ChAT: AB-N34AP
  • NGFr (ME20.4, p75): AB-N07
  • OX7 (Anti-Thy 1.1): AB-N08
  • Basigin-2: AB-42
  • TrkA: AB-N03

Gangsta Gallery

Targeting Technology Tutorial

Targeting Teaser (Jumble)