Targeting Trends Newsletter 10q4

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Newsletter Highlights

  • $3 Million Award (page 2)
  • Teaser Winners (page 2)
  • Anti-DBH-SAP tracer (page 5)
  • GAT1-SAP (page 7)
  • Complete and Submit the Targeting Teaser online!

Targeted Ablation of Sympathetic Neurons Reduces Ventricular Arrhythmias and Autonomic Dysreflexia – read article (continued on page 6)

Contributed by Heidi L. Lujan and Stephen E. DiCarlo
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201

Product information related to cover article: CTB-SAP (Cat. #IT-14)

$3 Million Award to Develop Cancer Pain Drug (continued on page 6) – Read press release

Targeting Teaser Winners

Upcoming Events

  • Society for Neuroscience (SFN) • November 14-17, 2010 • San Diego, CA • Booth #3525
  • American Association for Cancer Research (AACR) • April 2-6, 2011 • Orlando, FL

Recent Scientific References (read online)

  • Joseph EK, Levine JD (2010) Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat. Neuroscience 171(1):344-350. (Cat. #IT-10)
  • Zikri NN, Schumer E, Wang JJ, Gaughan A, Hadley GA, Moffatt-Bruce SD (2010) Induction of CD4(+)CD25(+) T regulatory cells with CD103 depletion. J Surg Res 163(1):162-168. (Custom Conjugates)
  • Kuroda K, Liu H, Kim S, Guo M, Navarro V, Bander NH (2010) Saporin toxin-conjugated monoclonal antibody targeting prostate-specific membrane antigen has potent anticancer activity. Prostate 70(12):1286-1294. (Cat. #IT-27)
  • Lecourtier L, de Vasconcelos AP, Leroux E, Cosquer B, Geiger K, Lithfous S, Cassel JC (2010) Septohippocampal pathways contribute to system consolidation of a spatial memory: Sequential implication of gabaergic and cholinergic neurons. Hippocampus. (Cat. #IT-01; Cat. #IT-20)
  • Baskin DG, Kim F, Gelling RW, Russell BJ, Schwartz MW, Morton GJ, Simhan HN, Moralejo DH, Blevins JE (2010) A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain. Endocrinology 151(9):4207-4213. (Cat. #IT-46; Cat. #IT-21)
  • Carvalho AF, Reyes AR, Sterling RC, Unterwald E, Van Bockstaele EJ (2010) Contribution of limbic norepinephrine to cannabinoid-induced aversion. Psychopharmacology (Berl) 211(4):479-491. (Cat. #IT-03; Cat. #PR-01)
  • Northrop LE, Polston EK, Erskine MS (2010) Noradrenergic Nuclei that Receive Sensory Input During Mating and Project to the Ventromedial Hypothalamus Play a Role in Mating-Induced Pseudopregnancy in the Female Rat. J Neuroendocrinol 22(10):1061-1071. (Cat. #IT-03; Cat. #IT-18)
  • Ariyama H, Kono N, Matsuda S, Inoue T, Arai H (2010) Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem 285(29):22027-22035. (Cat. #AB-259)
  • Adachi T, Huxtable AG, Fang X, Funk GD (2010) Substance P modulation of hypoglossal motoneuron excitability during development: changing balance between conductances. J Neurophysiol 104(2):854-872. (Cat. #AB-N04)
  • Wang Y, Mu X, Liu Y, Zhang X, Wu A, Yue Y (2010) NK-1-receptor-mediated lesion of spinal post-synaptic dorsal column neurons might improve intractable visceral pain of cancer origin. Med Hypotheses. (Cat. #IT-11)
  • Sugiura A, Ohtori S, Yamashita M, Yamauchi K, Inoue G, Suzuki M, Norimoto M, Orita S, Eguchi Y, Kuniyoshi K, Ochiai N, Kishida S, Takaso M, Aoki Y, Ishikawa T, Arai G, Miyagi M, Kamoda H, Nakamura J, Takahashi K (2010) Effect of applying p75NTR saporin to a punctured intervertebral disc on calcitonin gene-related peptide expression in rat dorsal root ganglion neurons. J Orthop Sci 15(3):407-413. (Cat. #IT-01)
  • Berg K, Weyergang A, Prasmickaite L, Bonsted A, Hogset A, Strand MT, Wagner E, Selbo PK (2010) Photochemical internalization (PCI): a technology for drug delivery. Methods Mol Biol 635:133-145. (Cat. #IT-27)
  • Potes CS, Turek VF, Cole RL, Vu C, Roland BL, Roth JD, Riediger T, Lutz TA (2010) Noradrenergic neurons of the area postrema mediate amylin’s hypophagic action. Am J Physiol Regul Integr Comp Physiol 299(2):R623-631. (Cat. #IT-03; Cat. #IT-18)
  • Gonzalez-Menendez I, Contreras F, Cernuda-Cernuda R, Provencio I, Garcia-Fernandez JM (2010) Postnatal development and functional adaptations of the melanopsin photoreceptive system in the albino mouse retina. Invest Ophthalmol Vis Sci 51(9):4840-4847. (Cat. #AB-N38)
  • Thomsen MS, Hay-Schmidt A, Hansen HH, Mikkelsen JD (2010) Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain. Cereb Cortex 20(9):2092-2102. (Cat. #IT-01)
  • Ocampo-Garces A, Ibanez F, Perdomo G, Torrealba F (2010) Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. J Sleep Res. (Cat. #IT-20)

Targeting Talk (see text)

SFN 2010 Poster of the Year Award – application details

$3 Million Award to Develop Cancer Pain Drug (continued from page 2)

Targeting Tools: Featured Products

Gangsta Gallery

Targeting Technology Tutorial

Targeting Teaser (Jumble)