Targeting Trends Newsletter 10q2

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Newsletter Highlights

  • New Catalog Available (page 2)
  • Orexin-SAP (page 5)
  • Teaser Winners (page 4)
  • Fab-ZAP, Anti-6 His-ZAP, Anti-GFP-ZAP (page 7)
  • Complete and Submit the Targeting Teaser online!

Depletion of syndecan-4+ T lymphocytes by saporin-conjugated DC-HIL alleviates T cell-mediated imflammatory disease. – read article (continued on page 6)

Contributed by Kiyoshi Ariizumi, Hideo Akiyoshi, Jin-Sung Chung, Mizuki Tomiharu, Ponciano D. Cruz Jr.
Department of Dermatology, The University of Texas Southwestern Medical Center and Dermatology Section (Medical Service), Dallas Veterans Affairs Medical Center, Dallas, TX

Product information related to cover article: Streptavidin-ZAP (Cat. #IT-27)

New Product Catalog Now Available

Targeting Teaser Winners

Upcoming Events

  • American Association for Cancer Research • April 17-21, 2010 • Washington, DC • Booth #2011
  • American Association of Immunologists • May 7-11, 2010 • Baltimore, MD • Booth #208

Recent Scientific References (read online)

  • Akasaka E, Watanabe S, Himaki T, Ohtsuka M, Yoshida M, Miyoshi K, Sato M (2010) Enrichment of xenograft-competent genetically modified pig cells using a targeted toxin, isolectin BS-I-B4 conjugate. Xenotransplantation 17:81-89. (Cat. #IT-10)
  • Akiyoshi H, Chung JS, Tomihari M, Cruz PD, Jr., Ariizumi K (2010) Depleting Syndecan-4+ T Lymphocytes Using Toxin-Bearing Dendritic Cell-Associated Heparan Sulfate Proteoglycan-Dependent Integrin Ligand: A New Opportunity for Treating Activated T Cell-Driven Disease. J Immunol 184:3554-3561. (Cat. #IT-27)
  • Browning PG, Gaffan D, Croxson PL, Baxter MG (2010) Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection. Cereb Cortex 20:282-293. (Cat. #IT-15)
  • Carstens EE, Carstens MI, Simons CT, Jinks SL (2010) Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats. Neuroreport 21:303-308. (Cat. #IT-11)
  • Conner JM, Kulczycki M, Tuszynski MH (2010) Unique Contributions of Distinct Cholinergic Projections to Motor Cortical Plasticity and Learning. Cereb Cortex [Epub Feb 24]. (Cat. #IT-01)
  • Dailey MJ, Bartness TJ (2010) Arcuate nucleus destruction does not block food deprivation-induced increases in food foraging and hoarding. Brain Res [Epub Feb 4]. (Cat. #IT-28; Cat. #IT-21)
  • Vincent BG, Young EF, Buntzman AS, Stevens R, Kepler TB, Tisch RM, Frelinger JA, Hess PR (2010) Toxin-Coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice. J Immunol [Epub Mar 10]. (Cat. #IT-27)
  • Zipancic I, Calcagnotto ME, Piquer-Gil M, Mello LE, Alvarez-Dolado M (2010) Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility. Cell Transplant [Epub Feb 8]. (Cat. #IT-11)
  • Cao F, Chen SS, Yan XF, Xiao XP, Liu XJ, Yang SB, Xu AJ, Gao F, Yang H, Chen ZJ, Tian YK (2009) Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin. Neurotoxicology 30:1096-1106. (Cat. #IT-12; Cat. #PR-01)
  • Harle P, Mobius D, Carr DJ, Scholmerich J, Straub RH (2005) An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum 52:1305-1313. (Cat. #IT-03)
  • Harle P, Pongratz G, Albrecht J, Tarner IH, Straub RH (2008) An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum 58:2347-2355. (Cat. #IT-03)
  • Itoi K, Sugimoto N (2010) The brainstem noradrenergic systems in stress, anxiety, and depression. J Neuroendocrinol [Epub Feb 20]. (Cat. #IT-03)
  • Lujan HL, Palani G, Zhang L, Dicarlo SE (2010) Targeted Ablation of Cardiac Sympathetic Neurons Reduces the Susceptibility to Ischemia-Induced Sustained Ventricular Tachycardia in Conscious Rats. Am J Physiol Heart Circ Physiol [Epub Feb 19]. (Cat. #IT-14)
  • Marques-Lopes J, Pinho D, Albino-Teixeira A, Tavares I (2010) The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A(5) noradrenergic cell group. Brain Res [Epub Feb 19]. (Cat. #IT-03)
  • Thomsen MS, Hay-Schmidt A, Hansen HH, Mikkelsen JD (2010) Distinct Neural Pathways Mediate {alpha}7 Nicotinic Acetylcholine Receptor-Dependent Activation of the Forebrain. Cereb Cortex [Epub Jan 4]. (Cat. #IT-01)
  • Vianna DM, Carrive P (2010) Cardiovascular and behavioural responses to conditioned fear and restraint are not affected by retrograde lesions of A5 and C1 bulbospinal neurons. Neuroscience 166:1210-1218.
    (Cat. #IT-03; Cat. #IT-18)

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