Targeting Trends Newsletter 08q4

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Newsletter Highlights

  • Melanopsin-SAP (page 2)
  • European office open (page 2)
  • Teaser Winners (page 5)
  • New Antibodies: HSA and Saporin (page 7)
  • Complete and Submit the Targeting Teaser online!

Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in conditioned fear. – read article (continued on page 6)

Contributed by Ekaterina Likhtik Columbia University, New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 Product information related to cover article: Dermorphin-SAP (Cat. #IT-12), Blank-SAP (Cat. IT-21)

Control Circadian Rhythm? (Melanopsin-SAP, Cat. #IT-44) – read article

Our New Office in Europe — Welcome Bas and Jan!

Recent Scientific References – read online

  • Pedrino GR, Rosa DA, Korim WS, Cravo SL (2008) Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons. Auton Neurosci [Epub Aug 8]. (Cat. #IT-03; Cat. #PR-01)
  • Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Hippocampus [Epub Jul 23]. (Cat. #IT-01)
  • Zhao XY, Liu HL, Liu B, Willuda J, Siemeister G, Mahmoudi M, Dinter H (2008) Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Transl Oncol 1:102-109. (Cat. #IT-04)
  • Bogen O, Joseph EK, Chen X, Levine JD (2008) GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci 28:12-19. (Cat. #IT-10)
  • Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Pare D (2008) Amygdala intercalated neurons are required for expression of fear extinction. Nature 454(7204):642-645. (Cat. #IT-12; Cat. #IT-21)
  • Zinck ND, Downie JW (2008) IB4 afferent sprouting contributes to bladder dysfunction in spinal rats. Exp Neurol 213:293-302. (Cat. #IT-10; Cat. #PR-01)
  • Colombari DS, Pedrino GR, Freiria-Oliveira AH, Korim WS, Maurino IC, Cravo SL (2008) Lesions of medullary catecholaminergic neurons increase salt intake in rats. Brain Res Bull 76:572-578. (Cat. #IT-03; Cat. #PR-01)
  • Li AJ, Dinh TT, Ritter S (2008) Hyperphagia and obesity produced by arcuate injection of NPY-saporin do not require upregulation of lateral hypothalamic orexigenic peptide genes. Peptides 29(10):1732-1739. (Cat. #IT-28; Cat. #IT-21)
  • Young EE, Baumbauer KM, Hillyer JE, Patterson AM, Hoy KC, Jr., Mintz EM, Joynes RL (2008) The neonatal injury-induced spinal learning deficit in adult rats: central mechanisms. Behav Neurosci 122:589-600. (Cat. #IT-07; Cat. #IT-21)
  • Mandolesi L, De Bartolo P, Foti F, Gelfo F, Federico F, Leggio MG, Petrosini L (2008) Environmental Enrichment Provides a Cognitive Reserve to be Spent in the Case of Brain Lesion. J Alzheimers Dis 15:11-28. (Cat. #IT-01)
  • Murillo-Rodriguez E, Liu M, Blanco-Centurion C, Shiromani PJ (2008) Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. Eur J Neurosci [Epub Sep 9]. (Cat. #IT-20)
  • Bienkowski MS, Rinaman L (2008) Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience [Epub Aug 13]. (Cat. #IT-03)

Targeting Talk (see text)

  • Saporin Clearance

Upcoming Events

  • Society for Neuroscience (SfN), Washington, D.C. — November 14-19, 2008 — Booth #523
  • American Society for Cell Biology, San Francisco, CA — December 12-17, 2008 — Booth #1543

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