Targeting Trends Newsletter 08q2

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Newsletter Highlights

  • ATS Licenses SP-SAP (page 2)
  • Upcoming Events (page 2)
  • Teaser Winners (page 4)
  • mu p75-SAP, WBLyse™, CFSE (page 7)
  • Complete and Submit the Targeting Teaser online!

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Selective lesion of basal forebrain cholinergic neurons in mice with the mu p75-saporin immunotoxin: Neuroanatomy and behavior – read article  (continued on page 6)

Contributed by Pierre-Henri Moreau, Brigitte Cosquer, Hélène Jeltsch, Jean-Christophe Cassel, Chantal Mathis
Laboratoire d’Imagerie et de Neurosciences Cognitives, UMR7191 CNRS, Equipe de Neurobiologie Cognitive et Comportementale, Université Louis Pasteur, IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France

Product information related to cover article: mu p75-SAP (Cat. #IT-16), 192-IgG-SAP (Cat. #IT-01)

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ATS Licenses SP-SAP to Advanced Pain Therapeutics – read article

Targeting Teaser Solution and Winners

Upcoming Events

  • Experimental Biology , San Diego CA, Booth #1135 — April 5-9, 2008
  • American Association for Cancer Research, San Diego, CA, Booth #1139 — April 12-16, 2008

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Recent Scientific References – read online

  • Moreau PH, Cosquer B, Jeltsch H, Cassel JC, Mathis C (2008) Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice. Hippocampus [Epub Feb 27]. (Cat. #IT-16Cat. #IT-01)
  • Pijpers A, Winkelman BH, Bronsing R, Ruigrok TJ (2008) Selective impairment of the cerebellar C1 module involved in rat hind limb control reduces step-dependent modulation of cutaneous reflexes. J Neurosci 28:2179-2189. (Cat. #IT-14)
  • Aztiria E, Cataudella T, Spampinato S, Leanza G (2008) Septal grafts restore cognitive abilities and amyloid precursor protein metabolism. Neurobiol Aging [Epub Feb 5]. (Cat. #IT-01)
  • Rostron CL, Farquhar MJ, Latimer MP, Winn P (2008) The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention? BMC Neurosci 9:16. (Cat. #IT-01)
  • Kline RHt, Wiley RG (2008) Spinal mu-opioid receptor-expressing dorsal horn neurons: role in nociception and morphine antinociception. J Neurosci 28:904-913. (Cat. #IT-12; Cat. #IT-21; Cat. #PR-01)
  • Kalinchuk AV, Porkka-Heiskanen T, McCarley RW (2006) Basal forebrain and saporin cholinergic lesions: the devil dwells in delivery details. Sleep 29:1385-1387; discussion 1387-1389. (Cat. #IT-01)
  • Newman LA, McGaughy J (2008) Cholinergic Deafferentation of Prefrontal Cortex Increases Sensitivity to Cross-Modal Distractors during a Sustained Attention Task. J Neurosci 28:2642-2650. (Cat. #IT-01)
  • Kaur S, Junek A, Black MA, Semba K (2008) Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in rats. J Neurosci 28:491-504. (Cat. #IT-01)
  • Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP (2008) Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology 54:269-279. (Cat. #IT-07Cat. #PR-01)
  • Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic
    cells. Neurotoxicology 28:1079-1091. (Cat. #IT-33)
  • Li A, Emond L, Nattie E (2008) Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function. Adv Exp Med Biol 605:371-376. (Cat. #IT-03; Cat. #IT-18)

Flow Cytometry Services (www.CytometryRes.com)

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Targeting Talk (see text)

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Selective lesion of BFCN with mu p75-SAP – read article (continued from page 1)

Do you have an idea for a new target? Contact us with your suggestion.

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Targeting Tools: Featured Products

  • mu p75-SAP (Cat. #IT-16) – read article
  • Flow Cytometry Tools (WBLyse™, Cat. #FL-08; CFSE Compensation Kit, Cat. #FL-13)

Gangsta Gallery

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Targeting Technology Tutorial

Targeting Teaser (Jumble)

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