Targeting Trends Newsletter 08q1

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Newsletter Highlights

  • Annual SfN Poster Award (page 2)
  • Upcoming Events (page 2)
  • Teaser Winners (page 4)
  • FGF-SAP, Anti-nAChR, and SP-CTA (page 7)

Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP – read article
(continued on page 6)

Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. Servatius Neuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ

Product information related to cover article: GAT1-SAP (Cat. #IT-32)

Annual Society for Neuroscience Poster Award (see winning abstract)
featuring Anti-GAT-SAP (Cat. #IT-32)

Upcoming Events

  • Experimental Biology , San Diego CA, Booth #1135 — April 5-9, 2008
  • American Association for Cancer Research, San Diego, CA, Booth #1139 — April 12-16, 2008

Recent Scientific References – read online

  • Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML (2007) Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther 6:2995-3008. (Cat. #PR-01)
  • Severino M, Pedersen AF, Trajkovska V, Christensen E, Lohals R, Veng LM, Knudsen GM, Aznar S (2007) Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex. Neurosci Lett 428:47-51. (Cat. #IT-01)
  • Berdiev RK, Chepurnov SA, Veening JG, Chepurnova NE, van Luijtelaar G (2007) The role of the nucleus basalis of Meynert and reticular thalamic nucleus in pathogenesis of genetically determined absence epilepsy in rats: A lesion study. Brain Res 1185:266-274. (Cat. #IT-01; Cat. #IT-18)
  • Frederick-Duus D, Guyton MF, Fadel J (2007) Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 149:499-507. (Cat. #IT-20)
  • Tait DS, Brown VJ (2008) Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats. Behav Brain Res 187:100-108. (Cat. #IT-01)
  • Chin JH, Ma L, MacTavish D, Jhamandas JH (2007) Amyloid beta protein modulates glutamate-mediated neurotransmission in the rat basal forebrain: involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors. J Neurosci 27:9262-9269. (Cat. #FL-01)
  • Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP (2007) Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology 54(2):269-279. (Cat. #PR-01; Cat. #IT-07)
  • Blanco-Centurion C, Gerashchenko D, Shiromani PJ (2007) Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci 27:14041-14048. (Cat. #IT-03; Cat. #IT-20; Cat. #IT-01)
  • Bavis RW, Powell FL, Bradford A, Hsia CCW, Peltonen JE, Soliz J, Zeis B, Fergusson ED, Fu Z, Gassmann M, Kim CB, Maurer J, McGuire M, Miller BM, O’Halloran KD, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Wilkinson KA (2007) Respiratory plasticity in response to changes in oxygen supply and demand Integ and Comp Biol 47(4):532-551. (Cat. #IT-07)

Targeting Talk

  • I’m using your secondary conjugate Mab-ZAP and it’s not killing my cells.
  • I have a question about what solutions might be incompatible with the conjugated saporins.

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