Targeting Trends Newsletter 02q2

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Newsletter Highlights

  • It’s Twins!(page 2)
  • Toxin Safety (page 5)
  • OX7-SAP (page 7)

HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not  – continued on page 2 and page 6

Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award. Note: HCRT-SAP is also known as orexin-SAP.

Product information related to cover article: Anti-DBH-SAP (Cat. #IT-03)

SP-SAP (Cat. #IT-07) Licensed to Cell Targeting Technologies

Matthew Kohls Welcomes the Diapered Duo

Recent Scientific References

Targeting Talk: Toxin Safety

  • Your recent issue of Targeting Trends stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned.
  • Are there any studies which indicate what doses of saporin (by itself or compounded with an antibody) would be hazardous if ingested or injected (i.e. systemic dose level resulting in death or organ dysfunction).

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: OX7 and OX7-SAP

Targeting Technology Tutorial

Targeting Teaser (Jumble)