Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak YS, & Markevich VA. Saporin from saponaria officinalis as a tool for experimental research, modeling, and therapy in neuroscience. (2020). Toxins, 12 (9):2020/08/29. 10.3390/toxins12090546

A review of studies where saporin-based conjugates were used to analyze cell mechanisms of sleep, general anesthesia, epilepsy, pain, and development of Parkinson’s and Alzheimer’s diseases.
IT-01: 192-IgG-SAP
IT-03: Anti-DBH-SAP
IT-06: Anti-Mac-1-SAP
IT-10: IB4-SAP
IT-15: ME20.4-SAP
IT-16: mu p75-SAP
IT-20: Orexin-B-SAP
IT-25: Anti-DAT-SAP
IT-32: Anti-GAT1-SAP
IT-34: Galanin-SAP
IT-40: Bombesin-SAP
IT-46: Oxytocin-SAP
IT-71: Anti-vGAT-SAP

Archer T, Kostrzewa RM. (2016) Neuroteratology and Animal Modeling of Brain Disorders. Curr Top Behav Neurosci 29:1-40. PMID: 26857462 (Targeting Trends 16q2)

Ng TB, Wong JH, Wang H (2009) Recent Progress in Research on Ribosome Inactivating Proteins. Curr Protein Pept Sci 1323:94-108. (Targeting Trends 10q2)

Wiley RG, Lappi DA (2005) Molecular Neurosurgery With Targeted Toxins. Humana Press Totowa, New Jersey. (Targeting Trends 05q3)

Lappi DA, Wiley RG (2004) Immunotoxins and neuropeptide-toxin conjugates experimental applications. Mini Rev Med Chem 4(5):585-595. (Targeting Trends 04q3)

Parent MB, Baxter MG (2004) Septohippocampal acetylcholine: involved in but not necessary for learning and memory? Learn Mem 11:9-20. (Targeting Trends 04q2)

Feldman JL, Mitchell GS, Nattie EE (2003) Breathing: Rhythmicity, Plasticity, Chemosensitivity. Annu Rev Neurosci 26:239-266. (Targeting Trends summary)

Madden CJ, Sved AF (2003) Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol Neurobiol 23(4-5):739-749. (Targeting Trends 04q1)

Pappas BA, Sherren N (2003) Neonatal 192 IgG-saporin lesion of forebrain cholinergic neurons: focus on the life span? Neurosci Biobehav Rev 27(4):365-376. (Targeting Trends 03q4)

Wiley RG, Lappi DA (2003) Targeted toxins in pain. Adv Drug Deliv Rev 55(8):1043-1054. (Targeting Trends 03q4)

Wiley RG (2001) Toxin-induced death of neurotrophin-sensitive neurons. (Review) Meth Mol Biol 169(1-2):217-222. (Targeting Trends summary)

Gu Z, Wortwein G, Yu J, Perez-Polo JR (2000) Model for aging in the basal forebrain cholinergic system. (Review) Antiox Redox Signal 2(3):437-447. (Targeting Trends summary)

McGaughy J, Everitt BJ, Robbins TW, Sarter M (2000) The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins. Behav Brain Res 115:251-263.

Sarter M, Bruno JP, Miner LA, McGaughy J (2000) Development of a method for intraparenchymal infusions of 192 IgG-Saporin: a comment on Pizzo et al. (1999) [letter; comment] J Neurosci Methods 96:169-170.

Wiley RG (2000) Neuropeptide-toxin conjugates in pain research and treatment. (Review) Reg Anesth Pain Med 25(5):546-548.

Detari L, Rasmusson DD, Semba K (1999) The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex. Prog Neurobiol 58:249-277.

Wiley RG (1999) Molecular Murder. Trends in Neurosci. 22(2):61.

McDonald MP, Overmier JB (1998) Present Imperfect: A Critical Review of Animal Models of the Mnemonic Impairments in Alzheimer’s Disease. Neurosci Biobehav Rev 22(1):99-120.

Rossner S (1998) Cholinergic immunolesions by 192 IgG-saporin–useful tool to simulate pathogenic aspects of Alzheimer’s disease. Int J Dev Neurosci 15:835-850.

Wrenn CC, Wiley RG (1998) The behavioral functions of the cholinergic basal forebrain: lessons from 192 IgG-Saporin. Int J Dev Neurosci 16:595-602.

Gallagher M (1997) Animal models of memory impairment. Philos Trans R Soc Lond [Biol] 352:1711-1717.

Picklo MJ (1997) Methods of sympathetic degeneration and alteration. J Auton Nerv Syst 62:111-125.

Wenk GL (1997) The nucleus basalis magnocellularis cholinergic system: one hundred years of progress. Neurobiol Learn Mem 67:85-95.

Wiley RG (1997) Findings about the cholinergic basal forebrain using immunotoxin to the nerve growth factor receptor. Ann N Y Acad Sci 835:20-29.

Wiley RG (1996) Targeting toxins to neural antigens and receptors. Sem Cancer Biol 7:71-77.

Gallagher M, Colombo PJ (1995) Ageing: the cholinergic hypothesis of cognitive decline. Curr Opin Neurobiol 5:161-168.

Picklo MJ, Wiley RG, Lonce S, Lappi DA, Robertson D (1995) Anti-dopamine b-hydroxylase immunotoxin induced sympathectomy in adult rats. J Pharmacol Exp Therap 275:1003-1010.

Wiley RG, Lappi DA (1994) Suicide Transport and Immunolesioning (Houston: R.G. Landes).

Contestabile A, Stirpe F (1993) Ribosome-inactivating proteins from plants as agents for suicide transport and immunolesioning in the nervous system. Eur J Neurosci 5:1292-1301.

Wiley RG (1992) Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning. TINS 15:285-290.