NK-1 Receptor Rabbit Polyclonal References

Cat #AB-N33AP

Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, & Osumi N. Structural and Functional Defects of the Respiratory Neural System in the Medulla and Spinal Cord of Pax6 Mutant Rats. (2019). Brain Research Bulletin, 152 107-116.

Objective:  To determine whether the respiratory center in the medulla functions normally in Pax6 mutant rats.
Summary:  The Pax6 gene is involved in the functional development of the medullary respiratory center.
Dose:  Anti-NK1r was used in immunofluorescence (1:800).

Fujita M, Fukuda T, Sato Y, Takasusuki T, & Tanaka M. Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model. (2018). Korean J Pain, 31 (1):10-15.

Objective: To identify a new strategy for postoperative pain management, this study investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and its effects on the activities of the primary afferent fibers at the dorsal horn.
Summary:  Systemic administration of Allopregnanolone inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allopregnanolone was proposed as a candidate for postoperative pain management.
Dose: Fluorescence immunohistochemistry: Six sections per animal were labeled with primary antiserum, rabbit anti-NK-1R (1:3,000).

Alvares TS, Revill AL, Huxtable AG, Lorenz CD, Funk GD. (2014) P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro. J Physiol 592(Pt 14):3089-3111. (Targeting Trends 14q3)

Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJr, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. (2013) Stable Respiratory Activity Requires Both P/Q-Type and N-Type Voltage-Gated Calcium Channels. J Neurosci 33(8):3633-3645. (Targeting Trends 13q2)

Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. (2013) Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther 347(2):258-264. (Targeting Trends 14q1)

Montandon G, Horner RL. (2013) State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo. J Neurosci 33(20):8716-8728. (Targeting Trends 13q3)

Choi JI, Koehrn FJ, Sorkin LS. (2012) Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain 8(1):4. (Targeting Trends 12q2)

Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL. (2011) PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. J Neurosci 31(4):1292-1301. (Targeting Trends 11q2)

Takasusuki T, Yaksh TL. (2011) The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg 112(4):971-976. (Targeting Trends 11q2)

Adachi T, Huxtable AG, Fang X, Funk GD (2010) Substance P modulation of hypoglossal motoneuron excitability during development: changing balance between conductances. J Neurophysiol 104(2):854-872. (Targeting Trends 10q4)

Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MCD, Ross SE, Hirata T, Corbin JG, Eugenin J, Del Negro CA (2010) Developmental origin of preBotzinger Complex respiratory neurons J Neurosci 30(44):14883-14895. (Targeting Trends 11q1)

Dhaka A, Earley TJ, Watson J, Patapoutian A (2008) Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J Neurosci 28(3):566-575.

Lorier AR, Huxtable AG, Robinson DM, Lipski J, Housley GD, Funk GD (2007) P2Y1 receptor modulation of the pre-Bˆtzinger complex inspiratory rhythm generating network in vitro. J Neurosci 27(5):993-1005.

Gu G, Kondo I, Hua XY, Yaksh TL (2005) Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther 314(3):1362-1369.

Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL (2005) Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25(14):3651-3660.

Pagliardini S, Adachi T, Ren J, Funk GD, Greer JJ (2005) Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bˆtzinger complex of rat medullary slice preparations. J Neurosci 25:2591-2596.

Pagliardini S, Ren J, Wevrick R, Greer JJ (2005) Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol 167(1):175-191.

Pagliardini S, Ren J, Greer JJ (2003) Ontogeny of the pre-Bˆtzinger complex in perinatal rats. J Neurosci 23(29):9575-9584.

Kummer W, Shigemoto R, Haberberger R (1999) Smooth muscle cells are the site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic nerve. Neurosci Lett 259(2):119-122.

Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, Li J, Daughters RS, Lappi DA, Wiley RG, Simone DA (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 278:275-279.

Vigna SR, Bowden JJ, McDonald DM, Fisher J, Okamoto A, McVey DC, Payan DG, Bunnett NW (1994) Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J Neurosci 14(2):834-845.

Shigemoto R, Nakaya Y, Nomura S, Ogawa-Meguro R, Ohishi H, Kaneko T, Nakanishi S, Mizuno N (1993) Immunocytochemical localization of rat substance P receptor in the striatum. Neurosci Lett 153(2):157-160.