Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, & Enz R. Localization of Group Ii and Iii Metabotropic Glutamate Receptors at Pre- and Postsynaptic Sites of Inner Hair Cell Ribbon Synapses. (2019). The FASEB Journal, 33 (12):13734-13746.
Application: immunohistochemistry (1:150)
Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, & Zachariou V. Rgs4 Maintains Chronic Pain Symptoms in Rodent Models. (2019). J Neurosci, 39 (42):8291.
Kamath P, & Chen A. Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells. (2018). Molecular Neurobiology
Objective: To investigate the roles of Mef2c in cerebellar Purkinje cells during the first three weeks of postnatal development.
Summary: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Results reveal the specific expression and functional relevance of Mef2c in developing Purkinje cells and offer insight to how disruption of the expression of Mef2c in a GABAergic neuronal subtype may lead to pathogenesis of cerebellar-associated disorders.
Dose: Immunohistochemistry – mouse anti-mGluR2 (1:1500)
Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM. (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34(1):79-94. (Targeting Trends 14q2)
Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF. (2011) TrkB (Tropomyosin-Related Kinase B) Controls the Assembly and Maintenance of GABAergic Synapses in the Cerebellar Cortex. J Neurosci 31(8):2769-2780. (Targeting Trends 11q2)
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1996) Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody. Neurosci Lett 202(3):197-200.
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1996) Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience 75(3):815-826.