Leptin-SAP References

Cat #IT-47

2020

Harris RBS. Loss of leptin-receptor expressing cells in the hindbrain decreases forebrain leptin sensitivity. (2020). Am J Physiol Endocrinol Metab    IT-21: Blank-SAP

Objective:  This study tested whether loss of hindbrain leptin receptor signaling changed sensitivity to forebrain leptin.
Summary:  Loss of VMH  (ventromedial nucleus of hippocampus) leptin receptor-expressing cells prevents weight loss.  The integrated response between the hindbrain and forebrain is heavily dependent upon leptin activity in the VMH.
Dose:  To test forebrain leptin sensitivity Leptin-SAP and Blank-SAP rats received third ventricle injections of 0, 0.05, 0.1, 0.25 or 0.5 μg leptin.

2019

Seamon M, Ahn W, Li A-J, Ritter S, & Harris RBS. Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. (2019). Am J Physiol Endocrinol Metab  PMID: 31361549

Objective: To test the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle leptin infusion.
Summary:  Leptin did not inhibit food intake and respiratory exchange ratio in rats treated with Leptin-SAP.  VMH leptin receptors do not play a significant role in maintaining energy balance in basal conditions, but limit weight gain during positive energy balance.
Dose: Bilateral VMH 75-nl injections of 260 ng/ml of Leptin-SAP or Blank-SAP.

2017

Challet E, Kalsbeek A. (2017) Editorial: Circadian Rhythms and Metabolism. Front Endocrinol (Lausanne) 8:201. PMID: 28861043

2013

Wiater MF, Li AJ, Dinh TT, Jansen HT, Ritter S. (2013) Leptin-sensitive neurons in the arcuate nucleus integrate activity and temperature circadian rhythms and anticipatory responses to food restriction. Am J Physiol Regul Integr Comp Physiol 305(8):R949-R960. (Targeting Trends 13q4)

2012

Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S. (2012) Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Am J Physiol Regul Integr Comp Physiol 302(11):R1313-26. (Targeting Trends 12q4)

2011

See: Society for Neuroscience 2011 Abstracts

2010

Li A-J, Wang Q, Dinh TT, Ritter S. (2010) Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats. Targeting Trends 11(1).