4 entries found for : it-39
Sleep-inducing effect of substance P-cholera toxin A subunit in mice.
Zielinski M, Gerashchenko D (2017) Sleep-inducing effect of substance P-cholera toxin A subunit in mice. Neurosci Lett 659:44-47.. doi: 10.1016/j.neulet.2017.08.066
Objective: To determine the effects of selectively activating SP-expressing brain cells on sleep regulation in mice.
Summary: ICV administration of SP-CTA produces increased amounts of NREM sleep but induces sleep fragmentation.
Usage: 1 mcg/mcl icv.
Related Products: SP-CTA (Cat. #IT-39)
Caudle R, King C, Nolan T, Suckow S, Vierck C, Neubert J (2010) Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin. J Pain 11:838-846. doi: 10.1016/j.jpain.2010.05.007
Objective: To understand central sensitization.
Summary: Findings suggest that central sensitization leads to activation of an endogenous opioid system. Intracisternal administration of SP-CTA is a useful model for studying central sensitization as a disease process without having to induce a peripheral injury.
Usage: SP-CTA was diluted in PBS and injected in a volume of 10 μl (rats) or 1 μl (mice) over the course of three minutes.
Related Products: SP-CTA (Cat. #IT-39)
Featured Article: Inducing central sensitization with a substance P/ cholera toxin conjugate
Caudle RM (2007) Featured Article: Inducing central sensitization with a substance P/ cholera toxin conjugate. Targeting Trends 8(4)
Related Products: SP-SAP (Cat. #IT-07), SP-CTA (Cat. #IT-39)
Read the featured article in Targeting Trends.
See Also:
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
Caudle RM (2007) Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. BMC Neuroscience 8:30. doi: 10.1186/1471-2202-8-30
Related Products: SP-CTA (Cat. #IT-39), Neurotensin-CTA (Cat. #IT-60)