GAT1-SAP References

Cat #IT-32


Maejima Y, Yokota S, Horita S, Shimomura K. The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. (2019) Sci Rep 9(1):11848. doi: 10.1038/s41598-019-48336-5

Objective:  To determine the underlying mechanisms that induce high energy intake (EI) per body weight (BW).
Summary:  Undeveloped properties of VTA GABA neurons in juvenile rats can promote higher EI regardless of high or less palatable feeding, and contribute to growth  promotion.
Dose:  GAT1-SAP or control, Rabbit IgG-SAP was bilaterally injected (0.025 μg/0.5 μl) into the VTA in eight-week-old adult rats.


REVIEW: Solari, N, Hangya, B. Cholinergic modulation of spatial learning, memory and navigation. (2018) Eur J Neurosci  48: 2199– 2230. doi: 10.1111/ejn.14089


Burjanadze M, Mataradze S, Rusadze K, Chkhikvishvili N, Dashniani M. (2015) Selective lesion of gaba-ergic neurons in the medial septum by gat1-saporin impairs spatial learning in a water-maze. Georgian Med News (240):59-64. (Targeting Trends 15q3)

Dashniani M, Kruashvili L, Rusadze Kh, Mataradze S, Beselia G. (2015) Effects of immunotoxic and electrolytic lesions of medial septal area on spatial short-term memory in rats. Georgian Med News (239):98-103. (Targeting Trends 15q3)


Roland JJ, Janke KL, Servatius RJ, Pang KC. (2014) GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Brain Struct Funct 219(4):1231-1237. (Targeting Trends 14q4)

Roland JJ, Stewart AL, Janke KL, Gielow MR, Kostek JA, Savage LM, Servatius RJ, Pang KC. (2014) Medial septum-diagonal band of Broca (MSDB) GABAergic regulation of hippocampal acetylcholine efflux is dependent on cognitive demands. J Neurosci 34(2):506-514. (Targeting Trends 14q2)


Baxter MG, Bucci DJ. (2013) Selective Immunotoxic Lesions of Basal Forebrain Cholinergic Neurons: Twenty Years of Research and New Directions. Behav Neurosci 127(5):611-618. (Targeting Trends 13q4)

Koppen JR, Winter SS, Stuebing SL, Cheatwood JL, Wallace DG. (2013) Infusion of GAT1-saporin into the medial septum/vertical limb of the diagonal band disrupts self-movement cue processing and spares mnemonic function. Brain Struct Funct 218(5):1099-1114. (Targeting Trends 12q4)


Pang KCH, Jiao X, Sinha S, Beck KD, Servatius RJ (2011) Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: Effects on proactive interference. Hippocampus 21(8):835-846. (Targeting Trends 11q1)

Radley JJ, Sawchenko PE. (2011) A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response. J Neurosci 31(26):9683-9695. (Targeting Trends 11q3)

See also: Society for Neuroscience 2011 Abstracts


See also: Society for Neuroscience 2010 Abstracts


Radley JJ, Gosselink KL, Sawchenko PE (2009) A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. J Neurosci 29:7330-7340. (Targeting Trends 09q3)

See also: Society for Neuroscience 2009 Abstracts


Pang KCH, Jiao X, Servatius RJ. (2008) Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP. Targeting Trends 9(1).

See also: Society for Neuroscience 2008 Abstracts


McAuley J, Pang K (2007) Effects of NBM lesions on selective attention in an interval timing task. Soc Neurosci Mtg, San Diego CA. Abstract #742.9.