Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, & Wang F. Macrophage Migration Inhibitory Factor Mediates Peripheral Nerve Injury-Induced Hypersensitivity by Curbing Dopaminergic Descending Inhibition. (2018). Experimental &Amp; Molecular Medicine, 50 e445.
Dose: Anti-DAT-SAP was injected i.t. or i.c.v. with ISO-1 alone or ISO-1 combined with one of the other regulators on Day 7 post-nerve injury for 14 days, and pain behaviors, including 50% withdrawal threshold, mechanical pressure and thermal withdrawal latency, were observed throughout the 70 days post nerve injury.
Objective: To investigate whether the proinflammatory cytokine MIF participates in the regulation of neuropathic hypersensitivity by interacting with and suppressing the descending dopaminergic system.
Summary: MIF functions as a braking factor in curbing dopaminergic descending inhibition in peripheral nerve injury-induced hypersensitivity by mediating Th gene methylation through G9a/SUV39H1-associated H3K9 methylation.
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