OX7-SAP References

Cat. #IT-02 – discontinued


Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Browning PGF, Simón A-M, López-Téllez JF, Jiménez-Recuerda I, Martîn-Montañez E, Pérez-Mediavilla A, Frechilla D, Baxter MG, Khan ZU. Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases. (2020) Neuroscience 448:287-298. doi: 10.1016/j.neuroscience.2020.08.039


Masmudi‐Martin M, Navarro‐Lobato I, López‐Aranda MF, Delgado G, Martín‐Montañez E, Quiros‐Ortega ME, Carretero‐Rey M, Narváez L, Garcia‐Garrido MF, Posadas S, López‐Téllez JF, Blanco E, Jiménez‐Recuerda I, Granados‐Durán P, Paez‐Rueda J, López JC and Khan ZU. RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. (2019) FASEB J, 33: 11804-11820. doi: 10.1096/fj.201900429RR

Objective:  To investigate the effect of the promotion of neuronal arborization through the expression of the regulator of G-protein signaling 14 of 414 amino acids (RGS14414).
Summary:  In addition to showing the potential of RGS14414 for rescuing memory deficits, our results suggest that a boost in circuit activity could facilitate memory enhancement and the reversal of memory deficits.
Dose:  0.9 mg in 1 ml was injected into the PRh.


Baxter MG, Bucci DJ. (2013) Selective Immunotoxic Lesions of Basal Forebrain Cholinergic Neurons: Twenty Years of Research and New Directions. Behav Neurosci 127(5):611-618. (Targeting Trends 13q4)

Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, Rosenblum MD. (2013) Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol 190(9):4483-4487. (Targeting Trends 13q3)

Mavrogenis AF, Pavlakis K, Stamatoukou A, Papagelopoulos PJ, Theoharis S, Zetahang Z, Soucacos PN, Zoubos AB. (2013) Intraneural OX7-saporin for neuroma-in-continuity in a rat model. Eur J Orthop Surg Traumatol 23(3):263-272. (Targeting Trends 13q2)


Huang TY, Lin LS, Cho KC, Chen SJ, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ. (2012) Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J Appl Physiol 113(6):889-895. (Targeting Trends 12q4)


Mendoza J, Pevet P, Felder-Schmittbuhl MP, Bailly Y, Challet E (2010) The cerebellum harbors a circadian oscillator involved in food anticipation. J Neurosci 30:1894-1904. (Targeting Trends 10q2)


Lopez-Aranda MF, Lopez-Tellez JF, Navarro-Lobato I, Masmudi-Martin M, Gutierrez A, Khan ZU (2009) Role of layer 6 of V2 visual cortex in object-recognition memory. Science 325:87-89. (Targeting Trends 09q4)

See also: Society for Neuroscience 2009 Abstracts


Traissard N, Herbeaux K, Cosquer B, Jeltsch H, Ferry B, Galani R, Pernon A, Majchrzak M, Cassel JC (2007) Combined damage to entorhinal cortex and cholinergic basal forebrain neurons, two early neurodegenerative features accompanying Alzheimer’s disease: effects on locomotor activity and memory functions in rats. Neuropsychopharmacology 32:851-871. (Targeting Trends 07q3)

Walker BR, Diefenbach KS, Parikh TN (2007) Inhibition within the nucleus tractus solitarius (NTS) ameliorates environmental exploration deficits due to cerebellum lesions in an animal model for autism. Behav Brain Res 176(1):109-120. (Targeting Trends 07q1)


Nolan BC, Freeman JH (2006) Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning. Learn Mem 13(3):359-365. (Targeting Trends 06q4)

Wiley RG. (2006) Targeted Toxins in Pain. Targeting Trends 7(2).


Nolan BC, Freeman JH Jr (2005) Purkinje cell loss by OX7-saporin impairs excitatory and inhibitory eyeblink conditioning. Behav Neurosci 119(1):190-201. (Targeting Trends 05q2)


Mattsson A, Pernold K, Ogren SO, Olson L (2004) Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. Neuroscience 127(3):579-591. (Targeting Trends 04q4)


Lalonde R, Strazielle C (2003) The effects of cerebellar damage on maze learning in animals. Cerebellum 2(4):300-309. (Targeting Trends 04q4)

See: Society for Neuroscience 2003 Abstracts


Berchtold NC, Kesslak JP, Cotman CW (2002) Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res 68(5):511-521. (Targeting Trends 02q4)

Salo PT, Hogervorst T, Seerattan RA, Rucker D, Bray RC (2002) Selective joint denervation promotes knee osteoarthritis in the aging rat. J Orthop Res 20(6):1256-1264. (Targeting Trends 03q2)


Wrenn CC, Wiley RG (2001) Lack of effect of moderate Purkinje cell loss on working memory. Neurosci 107(3):433-45. (Targeting Trends 02q2)


Angner, R.T., Kelly, R.M., Wiley, R.G., Walsh, T.J., and Reuhl, K.R. (2000) Preferential destruction of cerebellar Purkinje cells by OX7-saporin. Neurotoxicol 21:395-403. (Targeting Trends 00q4)

Gandhi, C.C., Kelly, R.M., Wiley, R.G., and Walsh, T.J. (2000) Impaired acquisition of a Morris water maze task following selective destruction of cerebellar Purkinje cells with OX7-saporin. Behav Brain Res 109:37-47. (Targeting Trends 00q4)

Wiley, R.G. and Kline IV, R.H. (2000) Neuronal lesioning with axonally transported toxins. J Neurosci Meth 103:73-82. (Targeting Trends 01q2)


Waite, J.J., Wardlow, M.L. and Power, A.E. (1999) Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71:325-352.


Krum, J.M., Kenyon, K.L., and Rosenstein, J.M. (1997) Expression of blood-brain barrier characteristics following neuronal loss and astroglial damage after administration of anti-Thy-1 immunotoxin. Exp Neurol 146:33-45.

Salo, P.T., Theriault, E., and Wiley, R.G. (1997) Selective ablation of rat knee joint innervation with injected immunotoxin: a potential new model for the study of neuropathic arthritis. J Orthop Res 15:622-628.


Roberts, R.C., Strain-Saloum, C., and Wiley, R.G. (1995) Effects of suicide transport lesions of the striatopallidal or striatonigral pathways on striatal ultrastructure. Brain Res 710:227-237.

Vogt, B.A., Wiley, R.G., and Jensen, E.L. (1995) Localization of mu and delta opioid receptors to anterior cingulate afferents and projection neurons and input/output model of mu regulation. Exp Neurol 135:83-92.


Roberts, R.C., Harrison, M.B., Francis, S.M.N., and Wiley, R.G. (1993) Differential effects of suicide transport lesions of the striatonigral or striatopallidal pathways on subsets of striatal neurons. Exp Neurol 124:242-252.


Crino, P.B., Vogt, B.A., Volicer, V., Wiley, R.G. (1990) Cellular localization of serotonin 1A, 1B, and uptake sites in cingulate cortex of the rat. J Pharmacol Exp Therap 252:651-656.


Davis, T.L. and Wiley, R.G. (1989) Anti-Thy-1 immunotoxin, OX7-saporin, destroys cerebellar Purkinje cells after intraventricular injection in rats. Brain Res 504:216-222.

Marcucci, F., Lappi, D.A., Ghislieri, M., Martineau, D., Siena, S., Bregni, M., Soria, M., and Gianni, A.M. (1989) In vivo effects in mice of an anti-T cell immunotoxin. J Immunol 142:2955-2960.

Wiley, R.G., Stirpe, F., Thorpe, P., and Oeltmann, T.N. (1989) Neuronotoxic effects of monoclonal anti-Thy 1 antibody (OX7) coupled to the ribosome inactivating protein, saporin, as studied by suicide transport experiments
in the rat. Brain Res 505:44-54.


Thorpe, P.E., Brown, A.N.F., Bremner, J.A.G., Foxwell, B.M.J., and Stirpe, F. (1985) An immunotoxin composed of monoclonal anti-thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: potent antitumor effects in vitro and in vivo. JNCI 75:151-159.