This sample pack of targeted toxins is useful in studying various aspects of satiety, appetite, and metabolism. These conjugates are all expected to react in rat and mouse.
There is evidence that NPY can have an effect on oxytocin release, particularly in reproductive related organs and processes (corpus luteum, lactation, etc.). Leptin is a key component in many obesity studies.
The kit includes 10-microgram aliquots of three targeted toxins: NPY-SAP (Cat. #IT-28), Oxytocin-SAP (Cat. #IT-46), and Leptin-SAP (Cat. #IT-47). Each targeted toxin specifically eliminates cells that recognize and internalize the respective peptides: Neuropeptide Y (NPY), Oxytocin, or Leptin. Unconjugated Saporin (25 micrograms) is included as Control.