Interleukin-4 Mouse Recombinant [PRP-282CYT]

SKU: PRP-282CYT Categories: , Product Size: 5 ug, 20 ug, 1 mg | Host: E. coli |
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Interleukin-4 is a pleiotropic cytokine produced primarily by activated T lymphocytes, basophils and mast cells. Multiple immune response-modulating functions are performed by IL-4 on a variety of cell types and it has an important role in the regulator of isotype switching, induction of IgE production in B lymphocytes and differentiation of precursor T helper cells. IL-4 binds to both membrane-bound and secreted soluble IL-4 receptors.

Interleukin-4 mouse recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 120 amino acids and having a molecular mass of 13500 Dalton. The IL-4 is purified by proprietary chromatographic techniques and lyophilized from a concentrated (1 mg/ml) solution in water containing no additives. Purity is greater than 95.0% as determined by RP-HPLC and SDS-PAGE. The ED50 as determined by the dose-dependant proliferation of murine HT-2 cells is < 2 ng/ml, corresponding to a Specific Activity of 5×105 IU/mg.

Amino acid sequence: MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

Amino acid sequence: MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

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