CD8 Mouse Monoclonal, FITC-labeled [PRP-131ANT]

SKU: PRP-131ANT Categories: , Antibody Type: Monoclonal | Host: mouse | Reactivity: Human | Conjugate: FITC | Usage: cytotoxic, flow cytometry |

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognizes antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains.

Mouse anti-human CD8 is conjugated to FITC and purified over an ion exchange column. Protein concentration is 1 mg/ml in PBS (after reconstitution).

Reported to be effective for flow cytometry and is also weakly cytotoxic.

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