BDNF promotes the survival of neuronal populations in the central nervous system or those populations directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Mouse anti-human brain-derived neurotrophic factor (BDNF) is purified by ion exchange chromatography. The protein concentration is 1 mg/ml in PBS after reconstitution.
Reported to be effective for direct ELISA, western blot, immunoprecipitation, and immunohistochemistry.
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