IFN-gamma is produced by lymphocytes activated by specific antigens or mitogens. In addition to having antiviral activity, it has important immunoregulatory functions, is a potent activator of macrophages, and has anti-proliferative effects on transformed cells. It can also potentiate the antiviral and antitumor effects of the type I interferons.
Mouse anti-human interferon-gamma (IFN-gamma) is purified over an ion exchange column. Protein concentration is 1 mg/ml in PBS (after reconstitution).
Reported to be effective for direct ELISA, western blot, immuneprecipitation, immunohistochemistry, and intracellular staining. This antibody loses its antigen binding capacity when immobilized on plastic. Biological activity is determined by virus neutralization assay and MHC class II induction.
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