Active interleukin-12 (IL-12) is a p70 disulphide-linked dimer composed of p35 and p40 subunits. The protein is a pleiotropic cytokine produced primarily by antigen presenting cells and has multiple effects on T lymphocytes and natural killer cells in terms of stimulating cytotoxicity, proliferation, production of other cytokines and Th1 subset differentiation.
Rat anti-mouse interleukin-12 p40 (IL-12 p40) is purified over an ion exchange column. Protein concentration is 1 mg/ml in PBS (after reconstitution).
Reported to be effective for direct ELISA, immunoblotting, immunoprecipitation.
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