IL-7 is a cytokine important for B and T cell development. This cytokine and hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
Mouse anti-human interleukin-7 (IL-7) is purified over an ion exchange column. Protein concentration is 1 mg/ml in PBS (after reconstitution).
Reported to be effective for direct ELISA, western blot, immunoprecipitation, immunohistochemistry, and intracellular staining.
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