Interleukin-4 Rat Monoclonal [PRP-108ANT]

SKU: PRP-108ANT Category: Antibody Type: Monoclonal | Host: Rat | Reactivity: Mouse |Usage: ELISA, immunoblotting, immunohistochemistry, immunoprecipitation, intracellular staining |
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IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Rat anti-mouse interleukin-4 (IL-4) is purified over an ion exchange column. Protein concentration is 1 mg/ml in PBS (after reconstitution).

Reported to be effective for direct ELISA, western blot, immunoprecipitation, immunohistochemistry, and intracellular staining.

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