Influenza-B virus is a genus in the virus family Orthomyxoviridae. Influenza-B virus only infects humans and seals. The limited host range is in contrast with the wide range of hosts infected by influenza-A, although both viruses mutate through genetic drift and reassortment. Influenza-B virus evolves slower than the A strain and faster than the C strain. Even with the slower mutation rate, there is no lasting immunity. Influenza-B virus can be both spherical and filamentous, with approximately 500 surface projections made of hemagglutinin and neuramidase. The influenza-B virus genome consists of 14648 nucleotides of single-stranded RNA.
Allantoic fluid of 10 day old embryonated eggs, inoculated with influenza-B virus strain Malaysia/2506/04. The virus was purified by ultracentrifugation with a 10-40% sucrose gradient. Purity is greater than 90% as determined by SDS-PAGE. The virus solution contains STE, 0.1% sodium azide, and 0.005% thimerosal. The preparation is tested by anti-influenza-B antibodies in ELISA.
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