Dengue virus is caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae. Each serotype is sufficiently different from the other such that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and in mice Morpholino antisense oligos have shown specific activity against dengue virus.
Polyvalent dengue antigen is a 22 kDa protein that contains four dengue antigen subtypes. It is produced in E. coli and fused to a 6 His tag. The immunoreactive peptide spans from the viral envelope to the non-functional region. The antigen consists of 25% recombinant antigen from each of the dengue antigen subtypes. All four subtypes are recognized by the polyvalent antigen. The sensitivity and specificity reach approximately 93%-96% in dengue IgG and IgM ELISA assay. Purity is greater than 95% pure as determined by 10% PAGE followed by coomassie staining.
To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols