Dengue virus is caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae. Each serotype is sufficiently different from the other such that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and in mice Morpholino antisense oligos have shown specific activity against dengue virus.
The E. coli-derived recombinant protein contains the NS1 dengue virus full length type-2 immunodominant regions. The dengue protein is fused to 6His tag. It is purified by proprietary chromatographic technique. The protein is >90% pure as determined by PAGE followed by coomassie staining.
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