ME20.4-SAP Kit [KIT-15]

25 ug, 100 ug, 250 ug

a tool for eliminating cells that express p75NTR in multiple species; targeted via NGFR monoclonal antibody (ME20.4), eliminated via saporin
This kit includes ME20.4-SAP (Cat. #IT-15) plus Mouse IgG-SAP (Cat. #IT-18) and NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

SKU: KIT-15 Category:


ME20.4-SAP provides researchers with a powerful lesioning tool ‰- more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species, including rabbit and primate. Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75NTR)-positive cells in rabbit. Tissue-directed injection in primates causes loss of p75NTR-positive neurons. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

To eliminate p75NTR-expressing cells in mouse, use mu p75-SAP (Cat. #IT-16). To eliminate p75NTR-expressing cells in rat, use 192-IgG-SAP (Cat.#IT-01).

ME20.4-SAP specifically eliminates p75NTR-positive neurons.


To view protocol(s) for this and other products please visit:

View ME20.4-SAP Data Sheet
View Mouse IgG-SAP Data Sheet
View NGFr (ME20.4, p75) Mouse Monoclonal Data Sheet

View Related ME20.4-SAP References
View Related Mouse IgG-SAP References
View Related NGFr (ME20.4, p75) Mouse Monoclonal References

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