Obestatin is a peptide hormone that was originally identified as being derived from the same precursor protein as ghrelin, a well-known hormone that stimulates appetite. While ghrelin promotes hunger, obestatin was initially proposed to have opposite effects — reducing appetite and slowing gastrointestinal motility. There has been uncertainty and debate about the exact receptor for obestatin. Initially, it was thought to bind to GRP39 but as of now no definitive high-affinity, functional receptor for obestatin has been universally accepted. Because obestatin appears to act independently of ghrelin, yet comes from the same gene (preproghrelin), researchers are intrigued by post-translational regulation of hormone function, the potential of obestatin to act as a natural counterbalance to ghrelin and uncovering new signaling pathways and drug targets.
This targeted toxin recognizes cells that express the obestatin receptor in human. Obestatin-SAP is a chemical conjugate of the obestatin peptide and the ribosome-inactivating protein, saporin.
The following control is included for validating the specificity of the beta conjugate: Blank-SAP (Cat. #IT-21)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.