Anti-PDL1-SAP [BETA-014]


anti-human PD-L1-saporin

SKU: BETA-014 Category: Antibody Type: Polyclonal | Host: Rabbit | Reactivity: Human | Conjugate: streptavidin-saporin | Usage: eliminates cells |

PD-L1, Programmed death-ligand 1, also known as B7-H1 and CD274, is a cell surface glycoprotein and a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. PD-L1 has dual function: inhibition of activated effector T cells and co-stimulation of naive T cells. PD-L1 has also been shown to be up-regulated in cancer cells in order to invade the host immune system.  Anti-PD-L1-SAP could be used as an effective tool to study cancer and the immune system.

Anti-PD-L1-SAP eliminates cells expressing human PD-L1 (CD274, B7-H1).

BIgG-SAP rabbit (Cat. #IT-75) is included as a control.

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.