RGR is a putative retinal G-protein coupled receptor. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. RGR is expressed exclusively in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium, and Muller cells. The RGR gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).
This immunopurified rabbit polyclonal RGR opsin antibody is predicted to bind to RGR in several species. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Horse, Xenopus (100%); Bovine (94%); Mouse, Rat, Hamster, Elephant, Panda, Rabbit, Pig, Platypus (88%); Dog, Turkey, Chicken, Pufferfish, Zebrafish (81%). RGR antibody was raised against synthetic 16 amino acid peptide from 2nd extracellular domain of human RGR.
Applications include: IHC – Paraffin (9-17 mcg/ml).
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