NGFR (ME20.4, p75) Mouse Monoclonal [AB-N07]

$443.00

SKU: AB-N07 Category: Quantity: 50 ug | Antibody Type: Monoclonal | Host: mouse | Reactivity: cat, dog, human, pig, primate, rabbit, sheep | Conjugate: unconjugated | Usage: electron microscopy, flow cytometry, immunocytochemistry, immunohistochemistry, immunoprecipitation, radioimmunoassay |

The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.

This antibody recognizes the p75NTR (low affinity neurotrophin receptor) in human, primate, rabbit, sheep, dog, cat, and pig. It was derived from immunization of mice with WM245 melanoma cells. The antibody is routinely tested by flow cytometry.

Applications include flow cytometry, immunoprecipitation, immunohistochemistry, electron microscopy, immunocytochemistry, radioimmunoassay, and targeting.

keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, basal forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, ME20.4, p75, brain, neuroscience

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Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: Implications for bicuspid aortic valve-related aortopathy

Jiao J, Tian W, Qiu P, Norton EL, Wang MM, Chen YE, Yang B (2018) Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: Implications for bicuspid aortic valve-related aortopathy. J Thorac Cardiovasc Surg 156:515-522. doi: 10.1016/j.jtcvs.2018.02.087 PMID: 29653750

Objective: To develop an in vitro model with human-induced pluripotent stem cells (iPSCs) to evaluate the role of NOTCH1 in smooth muscle and endothelial cell differentiation.

Summary: NOTCH1 is critical in SMC and EC differentiation of iPSCs through neural crest stem cells and cardiovascular progenitor cells, respectively. NOTCH1gene mutations may potentially contribute to the development of thoracic aortic aneurysms by affecting SMC differentiation in some patients with bicuspid aortic valve-related aortopathy.

Usage: Immunofluorescence staining and flow cytometry was performed.

Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

Extracellular matrix from periodontal ligament cells could induce the differentiation of induced pluripotent stem cells to periodontal ligament stem cell-like cells

Hamano S, Tomokiyo A, Hasegawa D, Yoshida S, Sugii H, Mitarai H, Fujino S, Wada N, Maeda H (2017) Extracellular matrix from periodontal ligament cells could induce the differentiation of induced pluripotent stem cells to periodontal ligament stem cell-like cells. Stem Cells Dev 27:100-111. doi: 10.1089/scd.2017.0077 PMID: 29160151

Usage: Immunofluorescence staining (1:200 dilution)

Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

Directed differentiation of periocular mesenchyme from human embryonic stem cells

Lovatt M, Yam GH-F, Peh GS, Colman A, Dunn NR, Mehta JS (2018) Directed differentiation of periocular mesenchyme from human embryonic stem cells. Differentiation 99:62-69. doi: 10.1016/j.diff.2017.11.003 PMID: 29239730

Objective: Pluripotent stem cells are attractive sources of cells for regenerative medicine, because large numbers of therapeutically useful cells can be generated. However, a detailed understanding of how to differentiate clinically relevant cell types from stem cells is fundamentally required.

Summary: Identification of cells resembling periocular mesenchyme (POM) cells in the adult cornea, located in a niche between the trabecular meshwork and peripheral endothelium. The generation and expansion of POM is an important step in the generation of a number of cells types that could prove to be clinically useful for a number of diseases of the cornea.

Usage: 1:200 for flow cytometry and immunofluorescence.

Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

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NGFR Products:

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NGFR (mu p75) Rabbit Polyclonal (Cat. #AB-N01) | affinity-purified (Cat. #AB-N01AP) | biotin-labeled (Cat. #AB-N01AP-BT) | Cy3-labeled (Cat. #AB-N01AP-FL3) | Cy5-labeled (Cat. #AB-N01AP-FL5) | Alexa488-labeled (Cat. #AB-N01AP-FLA)

NGFR (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) | biotin-labeled (Cat. #AB-N07-BT) | Alexa488-labeled (Cat. #AB-N07-FLA)

192-IgG-SAP (Cat. #IT-01)

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Flow cytometry for AB-N07

Immunology

NGFR Antibodies

Staining for Flow Cytometry

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