Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
Mouse anti-human vimentin is purified by ion exchange column. It is conjugated to FITC. Protein concentration is 1 mg/ml in PBS (after reconstitution). Vimentin antibody will recognize most mammalian vimentin except mouse and rat.
Reported to be effective for immunohistochemistry.
To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols