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Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain

Burgess SE, Gardell LR, Xie Y, Ossipov MH, Vanderah TW, Malan TP, Porreca F, Lai J (2002) Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain. Neuroscience 2002 Abstracts 351.11. Society for Neuroscience, Orlando, FL. Summary: Abnormal pain from L5/L6 spinal nerve ligation (SNL) has been shown to require […]

Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain Read More »

Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat.

Tarpley JW, Martin WJ, Baldwin BS, Forrest MJ, MacIntyre DE (2000) Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat. Neuroscience 2000 Abstracts 633.18. Society for Neuroscience, New Orleans, LA. Summary: Sensory information is transmitted from the periphery to the spinal cord by distinct subsets of primary afferent neurons, including two major classes

Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat. Read More »

Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat

Walker JR, Ong A, Detloff MR (2019) Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat. Neuroscience 2019 Abstracts 572.09. Society for Neuroscience, Chicago, IL. Summary: Individuals with spinal cord injury (SCI) suffer a loss of motor and sensory function. The current standard of care to recover

Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat Read More »

GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex.

Kaushal R, Taylor B, Jamal A, Zhang L, Ma F, Donahue R, Westlund K (2016) GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex. Neuroscience 334:148-159. doi: 10.1016/j.neuroscience.2016.08.005 Summary: The goal of this study was to investigate the role of

GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex. Read More »

Parkinson’s Disease, Unsteady Gait, and the ChAT Walk

Targeting Topics /

Selective Cholinergic Depletion of Pedunculopontine Tegmental Nucleus Aggravates Freezing of Gait in Parkinsonian Rats.  Xiao, H, Li, M, Cai, J, et al. (2017). Neurosci Lett [Epub 10 August 2017]. PMID: 28803956 Many patients with advanced Parkinson’s disease suffer from gait and postural impairments.  The authors used Anti-ChAT-SAP (Cat. #IT-42) to specifically lesion neurons in the Pedunculopontine Tegmental Nucleus (PPTg) to examine the

Parkinson’s Disease, Unsteady Gait, and the ChAT Walk Read More »

Animal Models

Targeting Topics /

ATS Animal Models ATS offers many different Animal Model products and full kits for various disease and behavioral research applications. Animal Models Learn more about our Saporin-produced Animal Models. Choose the product links below for the Animal Model of your interest. Most Animal Models are ready in 2 weeks using our Saporin conjugate system to

Animal Models Read More »

Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat.

Wang F, Eisenach JC, Peters CM (2012) Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat. Neuroscience 2012 Abstracts 785.11. Society for Neuroscience, New Orleans, LA. Summary: Background and Objective: The percentage of patients that develop chronic postsurgical pain can range

Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat. Read More »

American Association of Immunologists, AAI 2023

Events /

May 12-14, Booth 5067 Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 5067, May 12-14 and find out how you can use Molecular Surgery. Curated Resources Saporin Uses in Immunology Immunology

American Association of Immunologists, AAI 2023 Read More »

Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice.

Pinto LG, Souza GR, Lopes AHP, Talbot J, Cunha FQ, Cunha TM, Ferreira SH (2013) Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice. Neuroscience 2013 Abstracts 256.15. Society for Neuroscience, San Diego, CA. Summary: Sensory information is transmitted from the periphery to the spinal cord by distinct subsets of primary

Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice. Read More »

Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds.

Vulchanova L, Stone LS, Olson T, Riedl MS, Elde R, Honda CN (1999) Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds. Neuroscience 1999 Abstracts 272.8. Society for Neuroscience, Miami, FL. Summary: The lectin IB4 binds to and is specifically taken up by a subset of small sensory neurons, proposed to play a role

Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds. Read More »

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