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Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat.

Wang F, Eisenach JC, Peters CM (2012) Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat. Neuroscience 2012 Abstracts 785.11. Society for Neuroscience, New Orleans, LA. Summary: Background and Objective: The percentage of patients that develop chronic postsurgical pain can range […]

Depletion of spinal norepinephrine increases the duration of postoperative pain related behaviors following acute plantar incision and partial nerve injury in the rat. Read More »

Animal Models

Targeting Topics /

ATS Animal Models ATS offers many different Animal Model products and full kits for various disease and behavioral research applications. Animal Models Learn more about our Saporin-produced Animal Models. Choose the product links below for the Animal Model of your interest. Most Animal Models are ready in 2 weeks using our Saporin conjugate system to

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American Association of Immunologists, AAI 2023

Events /

May 12-14, Booth 5067 Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 5067, May 12-14 and find out how you can use Molecular Surgery. Curated Resources Saporin Uses in Immunology Immunology

American Association of Immunologists, AAI 2023 Read More »

Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice.

Pinto LG, Souza GR, Lopes AHP, Talbot J, Cunha FQ, Cunha TM, Ferreira SH (2013) Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice. Neuroscience 2013 Abstracts 256.15. Society for Neuroscience, San Diego, CA. Summary: Sensory information is transmitted from the periphery to the spinal cord by distinct subsets of primary

Role of nonpeptidergic subset of primary afferent neurons in inflammatory hypernociception in mice. Read More »

Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds.

Vulchanova L, Stone LS, Olson T, Riedl MS, Elde R, Honda CN (1999) Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds. Neuroscience 1999 Abstracts 272.8. Society for Neuroscience, Miami, FL. Summary: The lectin IB4 binds to and is specifically taken up by a subset of small sensory neurons, proposed to play a role

Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds. Read More »

Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.

Vera-Portocarrero LP, Yie JX, Kowal J, Ossipov MH, King T, Porreca F (2006) Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 130(7):2155-2164. doi: 10.1053/j.gastro.2006.03.025 Summary: Here the authors investigated the role of ascending or descending pathways in the mediation of pain caused by pancreatitis. Rats received 1.5

Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Read More »

Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies

News Article /

Contributed by David J Flavell, PhD, The Simon Flavell Leukaemia Research Unit, Division of Cancer Sciences, University of Southampton Medical School, United Kingdom. I have asked Dr. Flavell to contribute an article on the clinical use of his saporin immunotoxins. Dr. Flavell’s research unit is named after his son, who died from leukemia. At that

Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies Read More »

Transmission of neuropathic pain by spinal neurons expressing the NPY Y1 receptor

Donahue RR, Corder GF, Mcnamara KC, Wiley RG, Taylor BK (2011) Transmission of neuropathic pain by spinal neurons expressing the NPY Y1 receptor. Neuroscience 2011 Abstracts 179.16. Society for Neuroscience, Washington, DC. Summary: Endogenous neuropeptide Y (NPY) acts at Y receptors in the dorsal spinal cord to exert a tonic inhibitory control of chronic allodynia

Transmission of neuropathic pain by spinal neurons expressing the NPY Y1 receptor Read More »

Gastrin-releasing peptide receptor in the spinal cord mediates mechanical allodynia following nerve injury

Li C, Back S, Lee J, Baek SK, Na H (2010) Gastrin-releasing peptide receptor in the spinal cord mediates mechanical allodynia following nerve injury. Neuroscience 2010 Abstracts 176.2/OO4. Society for Neuroscience, San Diego, CA. Summary: Gastrin-releasing peptide receptor (GRPR) has been suggested as an itch-specific gene in the spinal cord (Sun et al., Nature, 2009).

Gastrin-releasing peptide receptor in the spinal cord mediates mechanical allodynia following nerve injury Read More »

Spinal neurons that possess the substance P receptor (SPR) modulate descending systems that control excitability of spinal nociceptive neurons

Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA (2003) Spinal neurons that possess the substance P receptor (SPR) modulate descending systems that control excitability of spinal nociceptive neurons. Neuroscience 2003 Abstracts 13.3. Society for Neuroscience, New Orleans, LA. Summary: We have recently shown that ablation of spinal SPR-expressing spinal neurons by intrathecal application of the

Spinal neurons that possess the substance P receptor (SPR) modulate descending systems that control excitability of spinal nociceptive neurons Read More »

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