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Consequences of the ablation of non-peptidergic nociceptive fibers on neurokinin-1 receptor expression by spinal lamina I neurons

Saeed AW, Ribeiro-Da-Silva A (2011) Consequences of the ablation of non-peptidergic nociceptive fibers on neurokinin-1 receptor expression by spinal lamina I neurons. Neuroscience 2011 Abstracts 804.21. Society for Neuroscience, Washington, DC. Summary: Spinal dorsal horn lamina I projection neurons expressing the neurokinin-1 receptor (NK-1r) are important in relaying pain-related information from the periphery to the […]

Consequences of the ablation of non-peptidergic nociceptive fibers on neurokinin-1 receptor expression by spinal lamina I neurons Read More »

Facilitatory influences from the rostral ventromedial medulla (RVM) are required for pancreatic nociception

Vera-Portocarrero LP, Xie Y, King T, Lai J, Porreca F (2005) Facilitatory influences from the rostral ventromedial medulla (RVM) are required for pancreatic nociception. Neuroscience 2005 Abstracts 623.18. Society for Neuroscience, Washington, DC. Summary: Pain is a frequent complaint of patients with pancreatitis or pancreatic cancer. An animal model of pancreatitis induced by dibutyltin dichloride

Facilitatory influences from the rostral ventromedial medulla (RVM) are required for pancreatic nociception Read More »

Cover Article: Impairments in gait, posture and complex movement control in rats modeling the multi-system, cholinergic-dopaminergic losses in Parkinson’s Disease

News Article /

by Aaron Kucinski (Collaborators at University Michigan, Ann Arbor: K. Phillips, R. Albin, M. Sarter) In addition to the primary disease-defining symptoms that result from extensive loss of nigrostriatal dopaminergic neurons, approximately half of patients with Parkinson’s Disease (PD) suffer from postural instability, impairments in gait control and a propensity for falls. These symptoms have

Cover Article: Impairments in gait, posture and complex movement control in rats modeling the multi-system, cholinergic-dopaminergic losses in Parkinson’s Disease Read More »

Responses of spinal dorsal horn neurons to capsaicin following intrathecal pretreatment with substance p-saporin toxin.

Khasabov SG, Rogers SD, Mantyh PW, Simone DA (2000) Responses of spinal dorsal horn neurons to capsaicin following intrathecal pretreatment with substance p-saporin toxin. Neuroscience 2000 Abstracts 635.13. Society for Neuroscience, New Orleans, LA. Summary: Intrathecal (i.t.) application of the cytotoxic substance P-saporin (SP-SAP) conjugate is internalized by dorsal horn neurons expressing the SP receptor

Responses of spinal dorsal horn neurons to capsaicin following intrathecal pretreatment with substance p-saporin toxin. Read More »

Spinal antinociceptive effect of gastrin releasing peptide (GRP) via GABAergic inhibitory interneurons expressing the GRP receptor (GRPR)

Akiyama T, Tominaga M, Davoodi A, Nagamine M, Takamori K, Carstens MI, Carstens E (2014) Spinal antinociceptive effect of gastrin releasing peptide (GRP) via GABAergic inhibitory interneurons expressing the GRP receptor (GRPR). Neuroscience 2014 Abstracts 158.02. Society for Neuroscience, Washington, DC. Summary: GRPR-expressing dorsal horn neurons signal itch. We investigated a role for such neurons

Spinal antinociceptive effect of gastrin releasing peptide (GRP) via GABAergic inhibitory interneurons expressing the GRP receptor (GRPR) Read More »

Generation of human melanocytes from induced pluripotent stem cells

Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y (2011) Generation of human melanocytes from induced pluripotent stem cells. PLoS One 6(1):e16182. doi: 10.1371/journal.pone.0016182 PMID: 21249204 Summary: For immunocytochemistry, cells were fixed with PBS containing 4% PFA for 20 min at room

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Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain

Burgess SE, Gardell LR, Xie Y, Ossipov MH, Vanderah TW, Malan TP, Porreca F, Lai J (2002) Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain. Neuroscience 2002 Abstracts 351.11. Society for Neuroscience, Orlando, FL. Summary: Abnormal pain from L5/L6 spinal nerve ligation (SNL) has been shown to require

Dermorphin-saporin targets descending facilitation in the rostral ventromedial medulla (rvm) to block CCK-induced abnormal pain Read More »

Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat.

Tarpley JW, Martin WJ, Baldwin BS, Forrest MJ, MacIntyre DE (2000) Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat. Neuroscience 2000 Abstracts 633.18. Society for Neuroscience, New Orleans, LA. Summary: Sensory information is transmitted from the periphery to the spinal cord by distinct subsets of primary afferent neurons, including two major classes

Contribution of IB4-positive sensory neurons to NGF-induced hyperalgesia in the rat. Read More »

Parkinson’s Disease, Unsteady Gait, and the ChAT Walk

Targeting Topics /

Selective Cholinergic Depletion of Pedunculopontine Tegmental Nucleus Aggravates Freezing of Gait in Parkinsonian Rats.  Xiao, H, Li, M, Cai, J, et al. (2017). Neurosci Lett [Epub 10 August 2017]. PMID: 28803956 Many patients with advanced Parkinson’s disease suffer from gait and postural impairments.  The authors used Anti-ChAT-SAP (Cat. #IT-42) to specifically lesion neurons in the Pedunculopontine Tegmental Nucleus (PPTg) to examine the

Parkinson’s Disease, Unsteady Gait, and the ChAT Walk Read More »

Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat

Walker JR, Ong A, Detloff MR (2019) Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat. Neuroscience 2019 Abstracts 572.09. Society for Neuroscience, Chicago, IL. Summary: Individuals with spinal cord injury (SCI) suffer a loss of motor and sensory function. The current standard of care to recover

Role of nociceptive afferent input on forelimb reaching and grasping behaviors in the spinal cord injured rat Read More »

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