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Breathing, Parkinson’s Disease and Targeting Orexin Receptors

Targeting Topics /

Orexin-B-SAP (Cat. #IT-20): a tool for eliminating cells that express the orexin-2 receptor; targeted via orexin-B peptide, eliminated via saporin. Orexinergic Neurons Are Involved in the Chemosensory Control of Breathing During the Dark Phase in a Parkinson’s Disease Model. Oliveira LM, Falquetto B, Moreira TS, & Takakura AC (2018) Exper Neurol, 309:107-118. Objective:  To determine […]

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Prefrontal cholinergic modulation of attentional performance-associated increases in posterior parietal acetylcholine release

Kozak R, Brown HD, Bruno JP, Sarter M (2006) Prefrontal cholinergic modulation of attentional performance-associated increases in posterior parietal acetylcholine release. Neuroscience 2006 Abstracts 369.15. Society for Neuroscience, Atlanta, GA. Summary: Increases in medial prefrontal cortex (mPFC) cholinergic activity were demonstrated to mediate attentional performance, particularly under conditions that require increases in attentional effort such

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Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature

Targeting Topics /

Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Patrick A. Shramm, Denise Higgins, Douglas A. Lappi • Advanced Targeting Systems, Carlsbad, CA Abstract Introduction: NPY-SAP is a conjugate of Neuropeptide Y and the ribosome-inactivating protein (RIP) saporin. The idea behind the invention of NPY-SAP is to introduce it using the ligand’s

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Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats

News Article /

Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region

Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats Read More »

NK1-expressing neurons critical for morphine reward behaviors in mice: C-fos expression and ablation of NK1-expressing neurons.

Gadd CA, Murtra P, Hall CN, Gana M, Webber MJ, De Felipe C, Hunt SP (2001) NK1-expressing neurons critical for morphine reward behaviors in mice: C-fos expression and ablation of NK1-expressing neurons. Neuroscience 2001 Abstracts 224.13. Society for Neuroscience, San Diego, CA. Summary: We have previously shown using conditioned place preference (CPP) that mice lacking

NK1-expressing neurons critical for morphine reward behaviors in mice: C-fos expression and ablation of NK1-expressing neurons. Read More »

Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents.

Kras J, Weisshaar C, Pall P, Winkelstein B (2015) Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents. Neurosci Lett 604:193-198. doi: 10.1016/j.neulet.2015.07.043 Summary: Both peptidergic and non-peptidergic neurons innervate the facet joint, which is the source of pain in a majority of neck trauma. In this work

Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents. Read More »

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q (2019) Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple

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Human embryonic stem cells form functional thyroid follicles

Ma R, Latif R, Davies TF (2015) Human embryonic stem cells form functional thyroid follicles. Thyroid doi: 10.1089/thy.2014.0537 PMID: 25585054 Summary: Lysates were prepared from single- and double-transfected cells by treating with 1 ·RIPA buffer for 20 min on ice. The samples were then centrifuged and treated with 5 · sample buffer at 100°C for

Human embryonic stem cells form functional thyroid follicles Read More »

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